| 林巧梅,袁益明.免疫衰老与慢性阻塞性肺疾病[J].中国临床保健杂志,2021,24(5):623-627. |
| 免疫衰老与慢性阻塞性肺疾病 |
| The relationship between immunosenescence and chronic obstructive pulmonary disease |
| 投稿时间：2021-05-13 |
| DOI：10.3969/J.issn.1672-6790.2021.05.009 |
| 中文关键词: 免疫衰老 肺疾病,阻塞性 全身炎症反应综合征 老年人 |
| 英文关键词: Immunosenescence Lung diseases,obstructive Systemic inflammatory response syndrome Aged |
| 基金项目:四川省科技厅重点攻关项目(2018SZ0171)；四川省干部保健高层次人才培养基金项目(2018) |
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| 中文摘要: |
| 免疫衰老是指随年龄增长而出现的免疫功能失调。在衰老进程中,机体适应性免疫系统的功能显著下降,而固有免疫系统代偿性增强,导致全身轻度持续的炎症反应。慢性阻塞性肺疾病(简称慢阻肺)是一种严重危害人类健康的常见病、多发病,其主要特征为持续存在的气流受限,通常是进行性的,与气道和肺部的慢性炎症反应有关。免疫衰老可能与慢阻肺的发病机制密切相关,了解免疫衰老可为慢阻肺治疗提供新的策略,现就免疫衰老及其与慢阻肺发生发展的关系作一概述。 |
| 英文摘要: |
| Immunosenescence refers to changes of immune function observed with aging.As our immune system alters with aging,innate immune is persistently activated response to compensate for the decline in the adaptive immune function,leading a persistent and mild systemic inflammation.Chronic obstructive pulmonary disease (COPD),a common preventable and treatable disease,is characterized by persistent airflow limitation,usually progressive and associated with chronic inflammation in the airways and the lung.Aging immune may be closely related to the pathogenesis of COPD.Understanding immunosenescence and the correlation between them may provide new strategies for the treatment of chronic obstructive pulmonary disease.This review will briefly describe the relationship between immunosenescence and the occurrence and development of COPD. |
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