| 郭亚威,王征,王长远,等.中性粒细胞与淋巴细胞比值联合序贯器官衰竭评分对老年脓毒症患者预后的评估价值[J].中国临床保健杂志,2021,24(5):628-631. |
| 中性粒细胞与淋巴细胞比值联合序贯器官衰竭评分对老年脓毒症患者预后的评估价值 |
| Prognostic value of neutrophil-lymphocyte ratio combined with SOFA score in elderly patients with sepsis |
| 投稿时间：2020-02-22 |
| DOI：10.3969/J.issn.1672-6790.2021.05.010 |
| 中文关键词: 脓毒症 器官功能障碍评分 预后 |
| 英文关键词: Sepsis Organ dysfunction scores Prognosis |
| 基金项目:国家自然科学青年基金项目(81801313) |
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| 中文摘要: |
| 目的 探讨中性粒细胞与淋巴细胞比值(NLR)联合序贯器官衰竭评分(SOFA)对老年脓毒症患者的病情和预后的评估价值。方法 选择首都医科大学宣武医院2018年6月至2019年6月急诊科住院的老年脓毒症患者131例,入院后给予血气分析及血常规等实验室检查,并进行SOFA评分和急性生理及慢性健康状况评分(APACHE Ⅱ)。所有入组老年脓毒症随访28 d,根据患者临床转归分成死亡组21例和生存组110例,比较两组患者白细胞计数(WBC)、NLR、SOFA评分和APACHE Ⅱ评分的区别,同时分析NLR、SOFA评分、APACHE Ⅱ评分、NLR联合SOFA评分预测老年脓毒症患者死亡的受试者工作特征(ROC)曲线下面积(AUC),并比较APACHE Ⅱ评分与其他研究指标AUC的区别。结果 死亡组患者NLR、SOFA评分、APACHE Ⅱ评分均大于生存组(P<0.01),两组WBC差异无统计学意义(P=0.539)；NLR预测老年脓毒症患者死亡的AUC为0.795(P=0.001),SOFA评分的AUC为0.775(P=0.001),APACHE Ⅱ 评分AUC为0.889(P=0.001)。APACHE Ⅱ 评分AUC大于NLR(P=0.047)。NLR联合SOFA评分的AUC为0.878(P=0.001),与APACHE Ⅱ评分的AUC差异无统计学意义(P=0.781),显著大于NLR(P=0.005)。结论 NLR联合SOFA评分预测老年脓毒症患者预后的临床价值与APACHE Ⅱ评分相近。 |
| 英文摘要: |
| Objective To study the prognostic value of neutrophil to lymphocyte ratio (NLR) combined with sequential organ failure assessment(SOFA) score in elderly patients with sepsis.Methods A total of 131 elderly patients with sepsis in the Department of Emergency,XuanWu Hospital of Capital Medical University were selected from June 2018 to June 2019.After admission,blood routine and blood gas analysis were performed.SOFA score and Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) were performed.Following up for 28 days,according to their prognosis,the patients were divided into death group (21 cases) and survival group (110 cases).The differences of WBC,NLR,SOFA score and APACHE Ⅱ score between the 2 groups were compared.Meanwhile,the area under Receiver Operation Characteristic (ROC) Curve for predicting the death of elderly sepsis patients was analyzed by NLR,SOFA score,APACHE Ⅱ score and NLR combined with SOFA score.The difference between APACHE Ⅱ score and the area under the curve (AUC) of other research indicators was also compared.Results NLR,SOFA scores and APACHE Ⅱ scores in the death group were higher than those in the survival group (P<0.01),and WBC was no significant difference in the two groups (P=0.539).The AUC of NLR in predicting the death of elderly sepsis patients was 0.795(P=0.001),the AUC of SOFA score was 0.775 (P=0.001),and the AUC of APACHE Ⅱ score was 0.889(P=0.001).The AUC of APACHE Ⅱ score was higher than that of NLR (P=0.047),and the AUC of NLR combined with SOFA score was 0.878 (P=0.001),which had no statistical difference compared with that of APACHE Ⅱscore (P=0.781),it was significantly greater than that of NLR (P=0.005).Conclusion The clinical value of NLR combined with SOFA score in predicting the prognosis of elderly patients with sepsis is similar to APACHE Ⅱ score. |
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