| 汪四海,方朝晖,忻凌,等.糖尿病足住院患者内服中药核心处方模式的数据挖掘研究[J].中国临床保健杂志,2021,24(5):646-651. |
| 糖尿病足住院患者内服中药核心处方模式的数据挖掘研究 |
| A data mining study on the core prescription model of internal Chinese Medicine for inpatients with diabetic foot |
| 投稿时间：2020-09-02 |
| DOI：10.3969/J.issn.1672-6790.2021.05.014 |
| 中文关键词: 糖尿病足 中草药 处方 数据挖掘 |
| 英文关键词: Diabetic foot Drugs,Chinese herbal Prescriptions Data mining |
| 基金项目:国家自然科学基金项目(81774286,81603574,81573944)；国家中医临床研究基地业务建设第二批科研项目(JDZX2015123)；国家重点研发计划“中医药现代化研究”重点项目(2018YFC1704202)；安徽省高校自然科学研究项目(KJ2018ZD029)；安徽省自然科学基金项目(1708085QH213)；国家重点研发计划项目(2019YFC1709203-4)；方朝晖安徽省名中医工作室资助项目(2019-8-515)；安徽中医药大学2020年自然科学研究重点项目(2020yfyzc24) |
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| 中文摘要: |
| 目的 基于医院信息系统研究糖尿病足住院患者隐含的内服中药处方模式,探索中医药治疗糖尿病足患者的用药规律。方法 本研究是基于中华人民共和国药典记录的草药,运用安徽中医药大学第一附属医院病例采集系统软件调取2013年6月至2018年12月在内分泌科住院并使用内服中药的糖尿病足患者726个处方的所用中药。频率和处方模式的关联规则使用SPSS Modeler 14.2数据挖掘系统进行分析。聚类分析使用SPSS 22.0统计软件进行。初步统计分析进行了分类:根据其药用草药的分类和用量,性、味、归经和功用。在分类的基础上,进行使用频率的计算。结果 (1)其中性寒、性温和性平的,味甘、味辛和味苦的及归脾胃经的草药使用最频繁；(2)益气健脾药、清热除湿药、活血化瘀药被频繁地使用；(3)中药的关联分析显示,置信度最高的三组药物:红花配伍桃仁(97.6%),丹参配伍桃仁(95.7%),丹参配伍桃仁、红花(95.6%) ；(4)聚类分析共聚为3类,体现了处方的配伍特点:以益气健脾为基础,同时兼顾活血化瘀、清热除湿。结论 糖尿病足与脾关系密切。这些处方重点为益气健脾、活血化瘀,其可能是治疗过程中的关键因素。同时,益气健脾药、活血化瘀药、清热除湿药的配伍是处方的基础。 |
| 英文摘要: |
| Objective Based on the hospital information system,we study the implicit pattern of internal Chinese medicine prescription in patients with diabetic foot to explore the medication rule of Chinese Medicine in patients with diabetic foot.Methods Based on herbs recorded in the pharmacopoeia of the People′s Republic of China,this study used the case collection system software of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine to retrieve traditional Chinese medicines of 726 prescriptions used by diabetic foot patients who were hospitalized in the endocrinology department and used internal Chinese medicine from June 2013 to December 2018.The association rules of frequency and prescription mode are analyzed using SPSS Modeler 14.2 data mining system.SPSS 22.0 statistical software was used for cluster analysis.Preliminary statistical analysis was made on the classification:according to its medicinal herbs classification and dosage,sex,taste,meridian and function.On the basis of classification,the frequency of use is calculated.Results (1) The herbs with cold,mild and flat nature,sweet,pungent and bitter taste and spleen and stomach meridian were most frequently used.(2) The medicines for invigorating qi and spleen,clearing heat and removing dampness,promoting blood circulation and removing blood stasis were frequently used.(3) Correlation analysis of traditional Chinese medicine showed that the three groups of drugs with the highest confidence:safflower matched with peach kernel (97.6%),salvia miltiorrhiza matched with peach kernel (95.7%),salvia miltiorrhiza matched with peach kernel and safflower (95.6%).(4) The cluster analysis is clustered into 3 categories,which reflected the compatibility characteristics of the prescription:it could promote blood circulation,remove blood stasis,clear heat and dehumidify at the same based on replenishing qi and strengthening the spleen.Conclusions There is a close relationship between diabetic foot and spleen.These prescriptions focus on replenishing qi and strengthening the spleen,promoting blood circulation and removing blood stasis,which may be the key factors in the treatment process.At the same time,the prescription is based on the compatibility of medicines for invigorating qi and spleen,promoting blood circulation and removing blood stasis,and clearing away heat and dehumidification. |
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