| 毛玉娣,赵卫刚,陈彦,等.老年衰弱与抗血小板药致消化道出血风险的相关性分析[J].中国临床保健杂志,2021,24(6):756-759. |
| 老年衰弱与抗血小板药致消化道出血风险的相关性分析 |
| Correlation between frailty and gastrointestinal bleeding caused by antiplatelet agents in the elderly |
| 投稿时间：2021-09-27 |
| DOI：10.3969/J.issn.1672-6790.2021.06.008 |
| 中文关键词: 胃肠道 衰弱 血小板聚集抑制剂 危险因素 老年人 |
| 英文关键词: Gastrointestinal tract Frailty Platelet aggregation inhibitors Risk factors Aged 〖FL |
| 基金项目:安徽省自然科学基金项目(1808085MH304)；安徽省公益性研究联动项目(1604f0804018) |
|
| 摘要点击次数: 2025 |
| 全文下载次数: 2762 |
| 中文摘要: |
| 目的 探讨老年衰弱水平与抗血小板药物导致消化道出血风险的相关性,为个体化治疗提供依据。方法 本研究主要收集使用抗血小板药物的老年住院患者80例,分为大便隐血阳性和大便隐血阴性组,对两组患者的临床资料进行比较,使用Spearman相关性分析及多因素logistic回归分析衰弱水平与大便隐血的关系。结果 与大便隐血阴性组相比,阳性组临床衰弱量表(CFS)评分较高,同时老年衰弱是服用抗血小板药物导致消化道出血的危险因素(OR=2.360,P=0.018),衰弱的严重程度与大便隐血阳性的风险呈正相关,即衰弱水平每增加1个等级,发生大便隐血阳性的平均风险大约增加1.360倍。而年龄和服用抗血小板药物种类对出血风险无统计学意义。结论 老年衰弱是服用抗血小板药物导致消化道出血的独立危险因素,建议用药前对老年患者进行衰弱评估,采取个体化治疗方案。 |
| 英文摘要: |
| Objective To explore the correlation between frailty and gastrointestinal bleeding caused by antiplatelet agents in the elderly and provide the evidence for individualized treatment.Methods A total of 80 elderly inpatients who taking antiplatelet agents were enrolled in our study,including the negative and positive group of fecal occult blood.Spearman correlation and Two-class logistic regression models were used to analyze the correlation between frailty degrees and the possibility of fecal occult blood.Results The higher CFS score was counted in positive group of fecal occult blood when compared with negative group.And our study showed that there were significant differences between frailty in elderly and gastrointestinal bleeding caused by antiplatelet agents(OR=2.360,P=0.018).The level of frailty was positively correlated with the positive rate of fecal occult blood and the average risk of bleeding increased by 1.360 times with the deterioration of frailty by degrees.But,there was no significant difference between the gastrointestinal bleeding and age and the types of antiplatelet agents.Conclusions Frailty in the elderly is an independent risk factor of gastrointestinal bleeding caused by antiplatelet agents,consequently,there is incorporation of the older individual′s frailty assessment to inform prognostication and treatment regime. |
|
查看全文
|
| 关闭 |
|
|
|