| 张啟维,石磊,薛庆云.骨科老年患者不同季节血清维生素D状态与骨代谢水平的研究[J].中国临床保健杂志,2022,25(1):37-40. |
| 骨科老年患者不同季节血清维生素D状态与骨代谢水平的研究 |
| Seasonal variation in serum vitamin D status and bone metabolism levels among older orthopedic patients |
| 投稿时间：2021-10-16 |
| DOI：10.3969/J.issn.1672-6790.2022.01.009 |
| 中文关键词: 维生素D 季节 骨生成 性别因素 老年人 |
| 英文关键词: Vitamin D Seasons Osteogenesis Sex factors Aged〖FL |
| 基金项目: |
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| 摘要点击次数: 2012 |
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| 中文摘要: |
| 目的 探究骨科老年患者血清维生素D水平与季节变化的关系及其引起的骨代谢变化特点。方法 调取2014年11月至2020年1月北京医院骨科1 831例老年患者血清25羟基维生素D(25-OH-D)、人血清和血浆中总Ⅰ型前胶原氨基端延长肽(tP1NP)、N端中段骨钙素(OCN)以及Ⅰ型胶原羧基端肽β特殊序列(β-CTX)检验结果,采用Mann-Whitney U检验分析不同季节患者血清25-OH-D及骨代谢指标水平特点,以及不同性别、不同就诊类型患者之间指标的差异。结果 血清25-OH-D水平无论季节变化,均处于维生素D缺乏状态,夏、秋两季血清25-OH-D水平明显高于冬、春两季(P<0.05),且夏、秋两季男性水平明显高于女性(P<0.05)；门诊患者一年四季血清25-OH-D水平均高于住院患者(P<0.001),tP1NP及β-CTX水平均低于住院患者(P<0.05)。结论 骨科老年患者维生素D水平夏秋季节最高；性别及就诊类型对维生素D和骨代谢指标的影响存在相关季节特点。 |
| 英文摘要: |
| Objective To investigate whether seasonal variation in serum 25-OH-D and bone metabolism levels among older orthopedic patients.Methods Serum 25-hydroxyvitamin D (25-OH-D),total procollagen type 1 amino-terminal propeptide (tP1NP),osteocalcin (OCN),and β-Crosslaps (β-CTX) was collected from elderly patients in the Department of Orthopedics of Beijing Hospital from November 2014 to January 2020.Total of 1 831 samples were analyzed by Mann-whitney U test to compare the levels of serum 25-OH-D,bone metabolism markers among different seasons,as well as the effect of gender and in or out patient.Results The level of serum 25-OH-D in summer and autumn was significantly higher than that in winter and spring (P<0.05),and the level of serum 25-OH-D in men was significantly higher than that in women (P<0.05).The serum 25-OH-D level in outpatients was higher than that in inpatients (P<0.001),and the levels of tP1NP and β-CTX were lower in inpatients (P<0.05) in all seasons.Conclusions The serum vitamin D level of elderly patients in orthopedics department is higher in summer and autumn.The effects of gender and in or out patient on vitamin D and bone metabolism markers are seasonal. |
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