| 柏慧,殷晓明,唐文娟,等.绝经后女性高血压患者雌二醇及同型半胱氨酸水平与血压昼夜节律变化对认知功能的影响[J].中国临床保健杂志,2022,25(1):75-78. |
| 绝经后女性高血压患者雌二醇及同型半胱氨酸水平与血压昼夜节律变化对认知功能的影响 |
| Effects of estradiol,homocysteine and circadian rhythm of blood pressure on cognitive function in the postmenopausal women paitents with hypertension |
| 投稿时间：2021-03-12 |
| DOI：10.3969/J.issn.1672-6790.2022.01.017 |
| 中文关键词: 高血压 绝经后期 雌二醇 半胱氨酸 认知功能障碍 女性 |
| 英文关键词: Hypertension Postmenopause Estradiol Cysteine Cognitive dysfunction Femininity 〖FL |
| 基金项目:安徽医科大学校青年基金项目(2018xkj083) |
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| 摘要点击次数: 1968 |
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| 中文摘要: |
| 目的 探讨绝经后女性高血压患者血清中雌二醇(E2)、同型半胱氨酸(Hcy)水平及昼夜血压节律变化与认知功能损伤的相关性。方法 选择2019年4月至2020年12月在安庆市立医院老年病科及全科医学科就诊的绝经后女性高血压患者51例,根据认知功能评估结果分为轻度认知障碍(MCI)组(n=27)和认知正常组(n=24)。比较两组患者一般情况、血清E2、Hcy及血压昼夜节律。结果 两组组间年龄、体重指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)及空腹血浆葡萄糖(FPG)差异无统计学意义。MCI组E2水平低于认知正常组,而Hcy水平高于认知正常组,差异均有统计学意义(P值均＜0.05)。MCI组血压昼夜节律异常率明显高于认知正常组,差异有统计学意义(χ2=4.403,P=0.036)。结论 绝经后女性高血压患者E2及Hcy水平变化,以及血压昼夜节律的改变可能与其认知功能发生损伤有关。 |
| 英文摘要: |
| Objective To explore the effects of estradiol,homocysteine and circadian rhythm of blood pressure on cognitive function in the postmenopausal women paitents with hypertension.Methods A total of 51 postmenopausal women paitents with hypertension admitted in our department from April 2019 to December 2020 were recruited in this study.According to the results of montreal cognitive assessment (MoCA),the patients were divided into mild cognitive impairment group (MCI group,n=27) and normal cognitive group (control group,n=24).The general conditions,the levels of E2,Hcy,circadian rhythm of blood pressure were compared between the two groups.Results There were no significant differences in general conditions between the 2 groups (P>0.05).E2 of the MCI group was lower than those of the normal group,while Hcy was higher than those of the normal group (P＜0.05).Compared with the normal group,the circadian rhythm of blood pressure were significantly higher in the MCI group (P＜0.05).Conclusions The levels of E2,Hcy and the changes in circadian rhythm of blood pressure may contribute to the cognitive function in the postmenopausal women paitents with hypertension. |
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