| 张强,宫健,程俊杰,等.血浆透析滤过与双重血浆分子吸附系统治疗肝衰竭患者的效果及对肝功能、 炎症细胞因子和凝血功能的影响[J].中国临床保健杂志,2022,25(1):101-105. |
| 血浆透析滤过与双重血浆分子吸附系统治疗肝衰竭患者的效果及对肝功能、 炎症细胞因子和凝血功能的影响 |
| Curative effect of plasma diafiltration and dual plasma molecular adsorption system on patients with liver failure and their influences on liver function,inflammatory cytokines and coagulation function indexes |
| 投稿时间：2021-05-21 |
| DOI：10.3969/J.issn.1672-6790.2022.01.024 |
| 中文关键词: 肝功能衰竭 血液透析滤过 双重血浆分子吸附系统 免疫调节 治疗结果 |
| 英文关键词: Liver failure Hemodiafiltration Dual plasma molecular adsorption system Immunomodulation Treatment outcome 〖FL |
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| 目的 探讨血浆透析滤过(PDF)与双重血浆分子吸附系统(DPMAS)治疗肝衰竭患者疗效及对肝功能、炎症细胞因子和凝血功能指标的影响。方法 选取2017年5月至2020年5月在山东省立第三医院诊治的100例肝衰竭患者,按照随机数字法分为对照组(50例)和观察组(50例)。对照组给予PDF治疗,观察组给予DPMAS治疗,比较两组临床疗效、肝功能指标[谷氨酸转氨酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)、胆碱酯酶(CHE)]、炎症细胞因子[白细胞介素10(IL-10)、转化生长因子β(TGF-β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)]、凝血功能指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)]、免疫功能及不良反应发生率。结果 观察组治疗有效率为76.0％,显著高于对照组的56.0％(P<0.05)；治疗前,两组ALT、ALB、TBIL、CHE、IL-10、TGF-β、IL-6、TNF-α、CRP、PT、TT、APTT、CD4+、CD8+、CD4+/CD8+水平比较,差异无统计学意义(P>0.05)；治疗后,观察组ALT、TBIL、IL-6、TNF-α、CRP、PT、TT、APTTs、CD8+水平均显著低于对照组,ALB、CHE、IL-10、TGF-β、CD4+、CD4+/CD8+水平均显著高于对照组(P<0.05)；两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 DPMAS治疗肝衰竭患者疗效显著,可改善肝功能和凝血功能,降低炎症因子水平,提高免疫功能。 |
| 英文摘要: |
| Objective To explore the curative effect of plasma diafiltration (PDF) and dual plasma molecular adsorption system (DPMAS) on patients with liver failure and their influences on liver function,inflammatory cytokines and blood coagulation indexes.Methods A total of 100 patients with liver failure treated in the hospital from May 2017 to May 2020 were enrolled and divided into control group (n=50) and observation group (n=50) according to random number table method.The control group was treated with PDF,while observation group was treated with DPMAS.The clinical curative effect,liver function indexes[alanine transaminase (ALT),aspartic albumin (ALB),total bilirubin (TBIL),cholinesterase (CHE)],inflammatory cytokines[interleukin-10 (IL-10),transforming growth factor-β (TGF-β),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),C-reactive protein (CRP)],coagulation function indexes[prothrombin time (PT),thrombin time (TT),activated partial thromboplastin time (APTT)],immune function and incidence of adverse reactions were compared between the two groups.Results The response rate of treatment in observation group was significantly higher than that in control group (76.0% vs.56.0%,P<0.05).Before treatment,there was no significant difference between the two groups in ALT,ALB,TBIL,CHE,IL-10,TGF-β,IL-6,TNF-α,CRP,PT,TT,APTT,CD4+,CD8+ or CD4+/CD8+(P>0.05).After treatment,ALT,TBIL,IL-6,TNF-α,CRP,PT,TT,APTT and CD8+ in observation group were significantly lower than those in control group,while ALB,CHE,IL-10,TGF-β,CD4+ and CD4+/CD8+ were significantly higher than those in control group (P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05).Conclusions Curative effect of DPMAS is significant on patients with liver failure.It can improve liver function and coagulation function,reduce levels of inflammatory factors,and improve immune function. |
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