| 朱志南,吴洪,朱晓丹,等.卧床继发多药耐药性重症肺炎老年患者外周血C反应蛋白和降钙素原动态变化及与预后的关系[J].中国临床保健杂志,2022,25(2):242-246. |
| 卧床继发多药耐药性重症肺炎老年患者外周血C反应蛋白和降钙素原动态变化及与预后的关系 |
| Dynamic changes of peripheral blood CRP and PCT in elderly bedridden patients with severe pneumonia secondary to multidrug resistance and their relationship with prognosis |
| 投稿时间：2021-10-21 |
| DOI：10.3969/J.issn.1672-6790.2022.02.025 |
| 中文关键词: 肺炎 抗药性,多药 C反应蛋白质 降钙素原 卧床者 预后 |
| 英文关键词: Pneumonia Drug resistance,multiple C-reactive protein Procalcitonin Bedridden persons Prognosis 〖FL |
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| 中文摘要: |
| 目的 探究卧床继发多药耐药性重症肺炎老年患者外周血C反应蛋白(CRP)、降钙素原(PCT)动态变化及与预后的关系。方法 回顾性选取2019年1月至2021年1月期间义乌市中心医院收治的120例卧床继发多药耐药性重症肺炎老年患者作为观察组,另选同期收治的卧床未合并多药耐药性重症肺炎老年患者120例作为对照组。收集患者性别、年龄、既往病史、病程等一般资料,按照临床肺部感染评分将120例观察组患者分为严重组(36例)和一般组(84例),并依据10 d内的预后情况将120例观察组患者分为生存组(68例)和死亡组(52例),分别检测患者入院第1天、第3天和第7天时外周静脉血CRP和PCT水平,受试者工作特征曲线(ROC)评估CRP和PCT动态变化水平对于预后的预测价值。结果 2组CRP和PCT组间、时间及交互差异均有统计学意义(P<0.001),观察组1 d、3 d和7 d时CRP和PCT均显著高于对照组(P<0.05),严重组1 d、3 d和7 d时CRP和PCT均显著高于一般组(P<0.05),死亡组1 d、3 d和7 d时CRP和PCT均显著高于生存组(P<0.05)。第7天血清CRP和PCT水平对于预后的效能较低(P>0.05),第3天血清CRP和PCT的水平高于129.80 mg/L和4.49 μg/L时对于预后的预测效能最佳,且CRP的诊断价值优于PCT(P<0.05)。结论 CRP和PCT水平与患者疾病严重程度和预后有关,动态监测CRP和PCT水平有利于临床评估患者预后。 |
| 英文摘要: |
| Objective To explore the dynamic changes of peripheral blood C-reactive protein (CRP) and procalcitonin (PCT) in elderly bedridden patients with severe pneumonia secondary to multidrug resistance and their relationship with prognosis.Methods One hundred and twenty elderly bedridden patients with severe pneumonia secondary to multidrug resistance in Yiwu Central Hospital between January 2019 and January 2021 were retrospectively selected as observation group,and another 120 elderly bedridden patients without multidrug resistance who were admitted during the same period were enrolled as control group.The general data such as gender,age,past medical history and course of disease were collected.According to the clinical lung infection score,120 patients in the observation group were divided into severe group (n=36) and general group (n=84),and based on the prognosis within 10 d,120 patients in the observation group were classified as survival group (n=68) and death group (n=52).Peripheral venous blood CRP and PCT levels were detected at 1 d,3 d and 7 d of admission.Receiver operating characteristic curve (ROC) was used to assess the predictive value of dynamic changes of CRP and PCT on the prognosis.Results There were statistically significant differences in the time-point and interaction effects of CRP and PCT between two groups (P<0.001).The levels of CRP and PCT of observation group were significantly higher than those of control group at 1 d,3 d and 7 d (P<0.05),and the levels were significantly higher in severe group than those in general group (P<0.05) and the levels were significantly higher in death group than those in survival group (P<0.05).The efficiency of serum CRP and PCT on prognosis was lower at 7 d of admission (P>0.05).When the levels of serum CRP and PCT at 3 d were higher than 129.80 mg/L and 4.49 μg/L,the predictive efficiency for prognosis was the best,and the diagnostic value of CRP was better than that of PCT (P<0.05).Conclusions CRP and PCT levels are related to the disease severity and prognosis of patients.Dynamic monitoring of CRP and PCT levels is helpful for clinical evaluation of prognosis of patients. |
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