| 刘岩,刘兵,李斯琪,等.血浆神经酰胺含量与动脉粥样硬化的相关性研究[J].中国临床保健杂志,2022,25(3):315-318. |
| 血浆神经酰胺含量与动脉粥样硬化的相关性研究 |
| Correlation between ceramide content in plasma and atherosclerosis |
| 投稿时间：2022-02-26 |
| DOI：10.3969/J.issn.1672-6790.2022.03.005 |
| 中文关键词: 神经酰胺类 动脉粥样硬化 气相色谱-质谱法 危险因素 |
| 英文关键词: Ceramides Atherosclerosis Gas chromatography-mass spectrometry Risk factors 〖FL |
| 基金项目:国家自然科学基金面上项目(82170297)；全军保健专项基金项目(19BJZ14) |
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| 中文摘要: |
| 目的 探讨血浆神经酰胺水平与动脉粥样硬化的相关性。方法 选取2019年8月1日至2020年7月31日北部战区总医院诊治的45~55岁动脉粥样硬化患者(AS组)114例,健康对照者(CO组)134例,应用高效液相色谱串联质谱法检测4种神经酰胺水平(Cer 16∶0、Cer 18∶0、Cer 24∶0、Cer 24∶1)并计算3种神经酰胺比值(Cer 16∶0/24∶0、Cer 18∶0/24∶0、Cer 24∶1/24∶0),研究神经酰胺水平与动脉粥样硬化的相关性。结果 AS组Cer 16∶0、Cer 18∶0、Cer 24∶1及Cer 18∶0/24∶0较CO组明显增高,差异有统计学意义(P<0.05)。按神经酰胺水平分3个风险等级,2组低、中、高风险等级所占人数比差异均有统计学意义(P<0.05),表明神经酰胺中、高风险水平与动脉粥样硬化呈正相关,神经酰胺低风险水平则与动脉粥样硬化呈负相关。应用二元logistic回归分析,对2组患者总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平进行校正,神经酰胺是动脉粥样硬化的独立危险因素[P<0.05,OR(神经酰胺中风险)=1.990,OR(神经酰胺高风险)=6.071]。结论 Cer 16∶0、Cer 18∶0、Cer 24∶1高水平与动脉粥样硬化的发生相关,是动脉粥样硬化的独立危险因素。 |
| 英文摘要: |
| Objective To study the correlation between plasma ceramide level and atherosclerosis.Methods One hundred and fourteen patients aged 45-55 years with atherosclerosis (AS group) and 134 healthy controls (CO group) were selected from August 2019 to July 2020 in General Hospital of Northern Theater Command.Four ceramide levels (Cer 16∶0,Cer 18∶0,Cer 24∶0,Cer 24∶1) and three ceramide ratio (Cer 16∶0/24∶0,Cer 18∶0/24∶0,Cer 24∶1/24∶0) were determined by HPLC-MS to study the relevance of ceramide levels and atherosclerosis.Results The levels of three kinds of ceramides (Cer 16∶0,Cer 18∶0 and Cer 24∶1) and Cer 18∶0/24∶0 in AS group were significantly higher than those in CO group (P<0.05).There were three risk levels according to ceramide level.There were significant differences in the proportion of low,medium and high risk levels between the two groups (P<0.05).The medium and high risk levels of ceramide were positively correlated with arteriosclerosis,while the low risk level of ceramide was negatively correlated with arteriosclerosis.Binary logistic regression analysis was used to correct the statistically significant levels of total cholesterol,low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the general data of the two groups.The results showed that plasma ceramide was an independent risk factor for atherosclerosis [P<0.05,OR(Ceramide medium risk)=1.990,OR(Ceramide high risk)=6.071].Conclusions The levels of different types of ceramide can be determined simultaneously by high performance liquid chromatography tandem mass spectrometry.The high levels of Cer 16∶0,Cer 18∶0 and Cer 24∶1 were associated with the occurrence of atherosclerosis.High plasma ceramide level is an independent risk factor for atherosclerosis. |
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