| 孙爽,付晗,安杨,马琳,朱强,崔俊昌,张歆刚.吸入型糖皮质激素对中老年中重度慢性阻塞性肺疾病患者肺癌发生风险的影响[J].中国临床保健杂志,2022,25(3):319-321. |
| 吸入型糖皮质激素对中老年中重度慢性阻塞性肺疾病患者肺癌发生风险的影响 |
| The effect of inhaled corticosteroids on the risk of lung cancer in middle-aged and elderly patients) with moderate to severe chronic obstructive pulmonary disease |
| 投稿时间：2022-01-10 |
| DOI：10.3969/J.issn.1672-6790.2022.03.006 |
| 中文关键词: 肺疾病,慢性阻塞性 肺肿瘤 糖皮质激素类 危险性评估 |
| 英文关键词: Pulmonary disease,chronic obstructive Lung Neoplasms Glucocorticoids Risk assessment 〖FL |
| 基金项目:国家重点研发计划资助项目(2016YFC1304300) |
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| 中文摘要: |
| 目的 探讨吸入型糖皮质激素(ICS)对中老年中重度慢性阻塞性肺疾病(COPD)患者肺癌发生风险的影响。方法 通过对中国人民解放军总医院第一医学中心病案数据库及COPD数据库中以“COPD合并肺癌”“COPD”为检索词收集2009年至2021年相关病例资料进行分析。COPD合并肺癌为COPD合并肺癌组,仅COPD为COPD组,比较两组资料年龄、性别、不良嗜好、吸烟时间及量、体重、COPD病程、ICS暴露情况进行分析；采用多元Cox比例风险回归分析肺癌发生的独立影响因素；应用Spearman秩相关分析探讨ICS暴露与否与肺癌发生的相关性。结果 对照组ICS暴露明显高于病例组(P＜0.05)。吸烟时间、吸烟量、COPD病程、确诊年龄、非ICS暴露均为发生肺癌的独立危险因素(P＜0.05)。ICS暴露与肺癌发生率的spearman秩相关系数为-0.700(P＜0.05)。结论 ICS暴露可降低中老年中重度COPD患者肺癌的发生风险。 |
| 英文摘要: |
| Objective To explore the effect of inhaled corticosteroids (ICS) on the risk of lung cancer in middle-aged and elderly patients with moderate to severe chronic obstructive pulmonary disease (COPD).Methods The data of relevant cases from 2009 to 2021 were collected and analyzed through the medical record database of the First Medical Center of the General Hospital of the People′s Liberation Army of China and the COPD database with "COPD combined with lung cancer" and "COPD".COPD combined with lung cancer was the case group,and only COPD was the control group.The age,gender,unhealthy habits,time and amount of smoking,weight,COPD course,and ICS exposure were compared between the two groups.Multivariate cox proportional risk regression was used to analyze the independent influencing factors of lung cancer.Spearman rank correlation analysis was used to explore the correlation between ICS exposure and the occurrence of lung cancer.Results The ICS exposure of the control group was significantly higher than that of the case group (P＜0.05).Smoking time,smoking amount,COPD course,age at diagnosis,and non-ICS exposure are all independent risk factors for lung cancer (P＜0.05).The Spearman rank correlation coefficient between ICS exposure and the incidence of lung cancer was -0.700 (P＜0.05).Conclusions ICS exposure reduces the risk of lung cancer in middle-aged and elderly patients with moderate to severe COPD. |
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