| 宋青青,范西真,付伟,崔东岳,王娟,王喆.达格列净治疗老年射血分数保留心力衰竭合并2型糖尿病患者的效果[J].中国临床保健杂志,2022,25(3):359-362. |
| 达格列净治疗老年射血分数保留心力衰竭合并2型糖尿病患者的效果 |
| Efficacy of dapagliflozin in the elderly patients with HF preserved ejection fraction and type 2 diabetes |
| 投稿时间：2022-02-19 |
| DOI：10.3969/J.issn.1672-6790.2022.03.016 |
| 中文关键词: 糖尿病,2型 心力衰竭 每搏输出量 钠-葡萄糖共转运蛋白2抑制剂 老年人 |
| 英文关键词: Diabetes mellitus,type 2 Heart failure Stroke volume Sodium-glucose transporter 2 inhibitors Aged 〖FL |
| 基金项目:安徽省重点研究与开发项目(1704f0804014) |
|
| 摘要点击次数: 1605 |
| 全文下载次数: 2383 |
| 中文摘要: |
| 目的 探讨达格列净治疗老年射血分数保留心力衰竭合并2型糖尿病患者的临床效果。方法 回顾性分析2020年9月至2021年3月中国科学技术大学附属第一医院(安徽省立医院)全科医学科住院的82例老年射血分数保留的心力衰竭合并2型糖尿病患者病历资料,根据用药方案分为对照组41例,达格列净组41例。2组均采用常规降糖药物及抗心力衰竭药物治疗,达格列净组加用达格列净10 mg/d,观察3个月。随访患者治疗前、治疗3个月后心功能指标血浆N末端B型利钠肽原(NT-proBNP)、患者6 min步行距离及再入院率。超声心动图参数包括:左心室舒张早期左房室瓣血流最大速度(E)/舒张早期左房室瓣环峰值速度(e′)、左心房容积指数(LAVI)、左心室射血分数(LVEF)等。结果 与对照组比较,达格列净组治疗3个月后LAVI、E/e′、C反应蛋白、NT-proBNP水平明显降低(P＜0.05)。达格列净组的6 min步行距离及LVEF较对照组明显提高(P＜0.05)。达格列净组和对照组随访3个月因心力衰竭再次住院患者分别为6例(14.6％)、14例(34.1％),差异有统计学意义(P=0.04)。结论 达格列净在老年射血分数保留心力衰竭合并2型糖尿病患者的治疗中能够改善患者的心力衰竭症状,降低再入院率。 |
| 英文摘要: |
| Objective To analyze the clinical efficicy of dapagliflozin in elderly HFpEF patients with type 2 diabetes.Methods Eighty-two elderly HFpEF patients with type 2 diabetes were divided into control group(n=41) and dapagliflozin treatment group(n=41),The all patients were received conventional medical treatment according to the blood glucose level and the NYHA classification.The drug group was combined with Dapag(10 mg/d),The echocardiography parameters(E/e′,LAVI,and LVEF),NT-proBNPand readmission rate were recorded before treatment and after 3 months of treatment.Results As compared with the control group,the patients in the dapagliflozin group had a significant decreased serum NT-proBNP,CRP,LAVI,E/e′(P<0.05),6MWT and LVEF were significantly improved in the dapagliflozin group.The patients in two groups were followed up for 3 months,during which 6 patients(14.6%) in dagliflozin treatment group and 14 patients(34.1%) in control group were readmitted due to HF.Conclusions Dapagliflozin can improve the cardiac function in elderly HFpEF patients with type 2DM and reduce readmission rate. |
|
查看全文
|
| 关闭 |
|
|
|