| 郑醒醒,吴蕾,杨晨,等.多系统萎缩患者跌倒风险及其危险因素的研究[J].中国临床保健杂志,2022,25(3):393-397. |
| 多系统萎缩患者跌倒风险及其危险因素的研究 |
| The prevalence and risk factors of falls in patients with multiple system atrophy |
| 投稿时间：2022-03-06 |
| DOI：10.3969/J.issn.1672-6790.2022.03.025 |
| 中文关键词: 多系统萎缩 意外跌倒 低血压,直立性 认知功能障碍 危险因素 |
| 英文关键词: Multiple system atrophy Accidental falls Hypotension,orthostatic Cognitive dysfunction Risk factors 〖FL |
| 基金项目:安徽省公益性技术应用研究联动计划项目(1704f0804011) |
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| 中文摘要: |
| 目的 了解多系统萎缩(MSA)患者的跌倒风险,并分析相关危险因素。方法 选取2019年7月至2021年7月于安徽医科大学附属省立医院诊断为“很可能的多系统萎缩”患者102例,根据过去3个月的跌倒史,将其分为跌倒组与未跌倒组。统计患者的一般资料,检查患者卧-立位血压情况、膀胱残余尿量,记录其共患病及使用药物的情况；使用统一多系统萎缩评定量表运动症状部分(UMSARS-Ⅱ)评估患者运动障碍程度,使用简明智力状态量表(MMSE)评估患者认知功能,使用Barthel指数评估患者日常生活活动能力。结果 62.7%的患者在过去3个月内发生过跌倒,MSA-P型与MSA-C型患者的跌倒率差异无统计学意义(61.2%比65.7%,P＞0.05)；跌倒组患者的MMSE评分及Barthel指数更低,UMSARS-Ⅱ评分更高,合并直立性低血压及使用镇静安眠药物的比例更高(P＜0.05)；logistic回归分析提示,存在直立性低血压(OR=3.761,95%CI:1.50~9.46,P＜0.05)及MMSE低评分(OR=0.857,95%CI:0.74~0.99,P＜0.05)是多系统萎缩患者跌倒的独立危险因素。结论 跌倒在多系统萎缩患者中相当普遍,存在直立性低血压及MMSE低评分是多系统萎缩患者跌倒的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the prevalence and risk factors of falls in patients with multiple system atrophy.Methods One hundred and two patients diagnosed with “probable MSA” were recruited from Provincial Hospital Affiliated to Anhui Medical University between July 2019 and July 2021.The patients were classified as fall group and non-fall group according to their fall experience in the last 3 months.The patients′ clinical data,including blood pressure status,function of the bladder,comorbidity,use of drugs and demographics information were collected.The second part of the Unified Multiple System Atrophy Rating Scale (UMSARS-Ⅱ) was used to assess the degree of motor impairment;the Mini-Mental State Examination (MMSE) was used to assess cognitive function and the Barthel Index was used to assess the patients’ ability to perform daily tasks.Results A total of 62.7% of the patients fell in the last 3 months,and there was no significant difference between the fall frequency of MSA-P and MSA-C (61.2% vs.65.7%,P>0.05).The fallers showed higher UMSARS-Ⅱscore and lower MMSE score,lower Barthel Index than the non-fallers.Furthermore,a higher percentage of patients in the fall group used sleeping pills and suffered from orthostatic hypotension (all P<0.05).According to the logistic regression showed,a lower MMSE score (OR=0.857,95%CI:0.74-0.99,P<0.05) were having orthostatic hypotension (OR=3.761,95%CI:1.50-9.46,P<0.05) were independent risk factors for falls in MSA patients.Conclusions Falls is common in patients with MSA,the orthostatic hypotension and MMSE score are its dependent risk factors. |
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