| 张莹,陈军梅,陈名涛,等.非小细胞肺癌根治性放化疗后血清外泌体来源的 microRNA-4429水平与预后的关系[J].中国临床保健杂志,2022,25(4):504-506. |
| 非小细胞肺癌根治性放化疗后血清外泌体来源的 microRNA-4429水平与预后的关系 |
| Relationship between serum excretion derived microRNA-4429 level and prognosis after radical radiotherapy and chemotherapy in NSCLC |
| 投稿时间：2022-05-13 |
| DOI：10.3969/J.issn.1672-6790.2022.04.016 |
| 中文关键词: 癌,非小细胞肺 化放疗 外泌体 微RNAs 危险因素 预后 |
| 英文关键词: Carcinoma,non-small-cell lung Chemoradiotherapy Exosomes MicroRNAs Risk factors Prognosis |
| 基金项目:湖北省自然科学基金项目(2018CFC885) |
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| 中文摘要: |
| 目的 探讨非小细胞肺癌(NSCLC)根治性放化疗后血清外泌体来源的microRNA-4429水平与预 后的关系。方法 选取2015年10月至2020年10月期间华润武钢总医院收治的120例NSCLC根治性放化疗 患者治疗前、治疗后的血液标本,采用实时荧光定量(PCR)技术检测microRNA-4429水平,分析microRNA- 4429水平与预后的关系。结果 2组患者在治疗前及治疗1个月microRNA-4429水平对比,差异无统计学意 义(P>0.05),治疗后3、6个月观察组microRNA-4429水平较对照组明显较高(P<0.05);治疗6个月诊断 NSCLC生存预后效能明显高于治疗1个月及治疗3个月(Z=3.587、2.608,P值均<0.05),microRNA-4429 水平与NSCLC患者生存预后存在线性关系(χ2=2.91,P<0.05),高microRNA组NSCLC患者生存预后的不良 风险发生率较低;分化程度、靶向治疗及microRNA-4429水平均是NSCLC患者生存预后的独立风险因素(P<0.05)。结论 microRNA-4429水平与NSCLC患者生存预后存在线性关系,水平越高预后不良风险性越低, 且分化程度、靶向治疗及microRNA-4429水平均为影响NSCLC患者生存预后的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the relationship between the level of serum secreted microRNA-4429 and prognosis of NSCLC after radical radiotherapy and chemotherapy.Methods The blood samples of 120 patients with NSCLC undergoing radical radiotherapy and chemotherapy from October 2015 to October 2020 were selected.The level of microRNA-4429 was detected by real-time fluorescence quantitative (PCR) technology,and the relationship between the level of microRNA-4429 and prognosis was analyzed.Results There was no significant difference in the level of microRNA-4429 between the two groups before and 1 month after treatment (P>0.05).The level of microRNA-4429 in the observation group was significantly higher than that in the control group 3 months and 6 months after treatment (P<0.05).The survival and prognosis efficiency of NSCLC patients diagnosed after 6 months of treatment was significantly higher than that after 1 month of treatment and 3 months of treatment (Z=3.587,2.608,P<0.05). There was a linear relationship between the level of microRNA-4429 and the survival and prognosis of NSCLC patients (χ2=2.91,P<0.05).The incidence of adverse risk of survival and prognosis of NSCLC patients in high microRNA group was lower.The degree of differentiation,targeted therapy and the level of microRNA-4429 were independent risk factors for the survival and prognosis of NSCLC patients (P<0.05).Conclusions There is a linear relationship between the level of microRNA-4429 and the survival and prognosis of NSCLC patients.The higher the level,the lower the risk of poor prognosis,and the degree of differentiation,targeted therapy and the level of microRNA-4429 are the risk factors affecting the survival and prognosis of NSCLC patients. |
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