| 宋诗涛,董吉云,陈继群,等.老年2型糖尿病患者血尿酸水平与糖脂代谢及颈动脉内膜中层厚度的关系[J].中国临床保健杂志,2022,25(4):515-518. |
| 老年2型糖尿病患者血尿酸水平与糖脂代谢及颈动脉内膜中层厚度的关系 |
| Relationship between serum uric acid level and glycolipid metabolism,arterial intima-media thickness in elderly patients with type 2 diabetes mellitus |
| 投稿时间：2022-05-22 |
| DOI：10.3969/J.issn.1672-6790.2022.04.019 |
| 中文关键词: 糖尿病,2型 尿酸 高尿酸血症 动脉粥样硬化 颈动脉内膜中膜厚度 老年人 |
| 英文关键词: Diabetes mellitus,type 2 Uric acid Hyperuricemia Atherosclerosis Carotid intima-media thickness Aged |
| 基金项目: |
|
| 摘要点击次数: 1637 |
| 全文下载次数: 2527 |
| 中文摘要: |
| 目的 探讨老年2型糖尿病(T2DM)患者血尿酸水平与颈动脉内膜中层厚度及糖脂代谢的关系。 方法 回顾性分析2018年3月至2020年2月入住合肥市第三人民医院的117例老年T2DM患者病历资料,为 研究组;选取同期接受体检的123例健康老年人资料,为对照组。比较2组的血尿酸水平、颈动脉内膜中层厚度 及糖脂代谢的差异,并采用亚组分析评估老年T2DM患者的血尿酸水平与颈动脉内膜中层厚度、糖脂代谢的相 关性。结果 相较于对照组,研究组的血尿酸水平、颈动脉内膜中层厚度均明显升高(P<0.05)。且研究组 的空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均高于对照组,而高密 度脂蛋白胆固醇(HDL-C)水平较对照组明显降低,差异均有统计学意义(P<0.05)。亚组分析显示:老年T2DM 患者的血尿酸水平与FBG、HbA1c、TG、TC、LDL-C、颈动脉内膜中层厚度呈正相关性(P<0.05),而与 HDL-C水平呈负相关性(P<0.05)。结论 老年T2DM患者的高尿酸血症与糖脂代谢、颈动脉内膜中层厚度均密 切相关,提示高尿酸血症可能作为评估老年T2DM患者动脉粥样硬化、糖脂代谢紊乱的辅助指标。 |
| 英文摘要: |
| Objective To investigate the relationship between serum uricacid level,intima-media thickness and glucolipid metabolism in elderly type 2 diabetes mellitus (T2DM) patients.Methods The medical records of 117 elderly patients with T2DM who were admitted to the Third People＇s Hospital of Hefei City from March 2018 to February 2020 were retrospectively analyzed,which were selected as the research group;the data of 123 healthy elderly patients who received physical examinations during the same period were selected as the control group.The differences of serum uric acid level,carotid intima media thickness,glucose and lipid metabolism between the two groups were compared,and the correlation between serum uric acid level and carotid intima media thickness,glucolipid metabolism in elderly T2DM patients was evaluated by subgroup analysis.Results Compared with the control group,serum uric acid level and carotid intima media thickness were significantly increased in the study group (P<0.05).The levels of fasting blood glucose (FBG),triglyceride (TG),total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the study group were higher than those in the control group,while the levels of high density lipoprote incholesterol (HDL-C) were significantly lower than those in the control group,the differences were statistically significant (P<0.05).Subgroup analysis showed that serum uric acid level was significantly positively correlated with FBG,HbA1c,LDL-C and carotid intima media thickness (P<0.05),and negatively correlated with HDL-C (P<0.05).Conclusions Hyperuricemia inelderly T2DM patients is closely related to glucose and lipid metabolism and carotid intima media thickness,suggesting that hyperuricemia may be an auxiliary indicator for assessing atherosclerosis and glucose and lipid metabolism disorders in elderly T2DM patients. |
|
查看全文
|
| 关闭 |
|
|
|