| 王晓丽,张爱君,赵卫东,等.自制一次性密闭式瘤体取出保护套在腹腔镜下子宫肌瘤分碎术中的应用[J].中国临床保健杂志,2022,25(4):530-533. |
| 自制一次性密闭式瘤体取出保护套在腹腔镜下子宫肌瘤分碎术中的应用 |
| The effects of insulin combined with saxagliptin on body weight and lipid metabolism in overweight type 2 diabetes mellitus |
| 投稿时间：2022-06-11 |
| DOI：10.3969/J.issn.1672-6790.2022.04.022 |
| 中文关键词: 糖尿病,2型 体重 血脂异常 胰岛素 二肽基肽酶Ⅳ抑制剂 |
| 英文关键词: Diabetes mellitus,type 2 Body weight Dyslipidemias Insulin Dipeptidyl-peptidase Ⅳ inhibitors |
| 基金项目:国家自然科学基金项目(82172773) |
|
| 摘要点击次数: 1638 |
| 全文下载次数: 5412 |
| 中文摘要: |
| 目的 探讨胰岛素联合沙格列汀治疗对超重2型糖尿病(T2DM)患者体重及脂代谢的影响。方 法 选取中国人民解放军总医院第二医学中心2018年1月至2019年12月治疗的T2DM患者102例为研究对 象,按照随机数字表法将其分为2组,每组51例。对照组给予胰岛素治疗,观察组在胰岛素治疗基础上联合沙 格列汀应用。治疗随访至12周末,比较2组空腹血糖(FBG)、餐后2 h血糖(P2hBG)、总胆固醇(TC)、三酰甘油 (TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)、体重指数(BMI)及低血糖事件发生率。 结果 治疗后对照组FBG、P2hBG、糖化血红蛋白、TG与观察组比较,差异无统计学意义;治疗后观察组TC[(1.13± 0.16) mmol/L比(4.64±0.31) mmol/L]、LDL-C[(2.67± 0.08) mmol/L比(4.17±0.21) mmol/L]及BMI[(22.57±2.68) kg/m2比(25.31±3.03) kg/m2]均低于对照组(P值均<0.05),HDL-C[(1.68±0.10) mmol/L比(1.36±0.05) mmol/L]高于对照组,差异有统计 学意义(P<0.05)。观察组胰岛素用量[(25.6±9.7) IU/d]显著低于对照组[(30.4±10.1) IU/d],P<0.05; 且低血糖发生率(7.8%比19.6%)显著低于对照组(P<0.05)。结论 T2DM患者给予胰岛素联合沙格列汀治 疗在有效降低血糖的同时,可以有效调节脂代谢,同时可以减少胰岛素用量,降低体重,安全性高。 |
| 英文摘要: |
| Objective To investigate the effects of insulin combined with saxagliptin on body weight and lipid metabolism in patients with over weight type 2 diabetes mellitus.Methods One hundredand two patients with type 2 diabetes from January 2018 to December 2019 in the Second Clinical Center of PLA General Hospital were selected and divided into two groups with 51 cases in each group.The control group was treated with insulin,and the observation group was treated with acombination of insulin and saxagliptin.The patients were followed up for 12 weeks.The levels of FBG,P2hBG,TC,TG,LDL-C,HDL-C,BMI and hypoglycemia events were compared between the two groups.Results No significant differences were found in FBG,P2hBG,HbA1c,TG between the control group and the observation group after treatment.TC[(1.13±0.16) mmol/L vs.(4.64±0.31) mmol/L],LDL-C[(2.67±0.08) mmol/L vs.(4.17±0.21) mmol/L] and BMI[(22.57±2.68) kg/m2 vs. (25.31±3.03) kg/m2] in the observation group were significantly lower than those in the control group (P<0.05), while HDL-C[(1.68±0.10) kg/m2 vs.(1.36±0.05) kg/m2] was significantly higher than that in the control group (P<0.05).The dosage of insulin in the observation group [(25.6±9.7) IU/d] was significantly lower than that in the control group [(30.4±10.1) IU/d],P<0.05,and the incidence of hypoglycemia events was significantly lower than that in the control group (7.8% vs.19.6%,P<0.05).Conclusions Insulin combined with saxagliptin can effectively reduce blood glucose,insulin dosage and body weight,regulate lipid metabolism with high safety. |
|
查看全文
|
| 关闭 |
|
|
|