| 夏霄霄,路秀文,黄桢雅,等.RELMs家族的相关研究进展[J].中国临床保健杂志,2022,25(4):555-561. |
| RELMs家族的相关研究进展 |
| Research progress of resistin-like molecules |
| 投稿时间：2022-05-20 |
| DOI：10.3969/J.issn.1672-6790.2022.04.029 |
| 中文关键词: RELMs家族 抵抗素 基因表达调控 综述 |
| 英文关键词: RELMs Resistin structure,mechanism Gene expression regulation Review |
| 基金项目:国家重点研发计划资助项目(2017YFC1307700) |
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| 中文摘要: |
| 抵抗素样分子家族(RELMs)是一类富含半胱氨酸的分泌蛋白家族,自2000年被Steppan等发现以来,已经相继有4个啮齿类动物亚型成员、2个人类亚型成员被证实。诸多研究表明RELMs家族与炎症反应、胰岛素抵抗、肺纤维化、血管重塑、动脉粥样硬化斑块形成等有密切关系,其在多学科疾病的发生发展中均起重要作用。该文就RELMs家族的结构以及在不同疾病中的主要功能及其调控机制作一综述。 |
| 英文摘要: |
| Resistin like molecule family (RELMs) is a family of cysteine-rich secreted proteins..Since they were discovered by Steppan et al.in 2000,four members of rodent subtypes and two members of human subtypes had been confirmed.Many studies had shown that RELMs are closely related to inflammatory response,insulinresistance,pulmonaryfibrosis,vascularremodeling,atherosclerotic plaque formation and so on.They play an important role in the occurrence and development of multidisciplinary diseases.This review summarized the research progress of RELMs on the molecular structure and main mechanisms in different diseases. |
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