文章摘要
高妍芬,宗刚军,葛青,施卫荣,陆晓丹.比索洛尔联合地高辛对老年慢性心力衰竭伴非阵发性心房颤动患者心功能的影响[J].中国临床保健杂志,2023,26(1):78-81.
比索洛尔联合地高辛对老年慢性心力衰竭伴非阵发性心房颤动患者心功能的影响
Effect of bisoprolol combined with digoxin on cardiac function in elderly patients with chronic heart failure and non paroxysmal atrial fibrillation
投稿时间：2022-11-19  
DOI：10.3969/J.issn.1672-6790.2023.01.017
中文关键词: 心力衰竭  心房颤动  地高辛  比索洛尔  老年人
英文关键词: Heart failure  Atrial fibrillation  Digoxin  Bisoprolol  Aged 〖FL
基金项目:江苏省卫生计生委科研项目(QNRC2016883)
作者单位E-mail
高妍芬 中国人民解放军联勤保障部队第九○四医院无锡市太湖医院,高干病房,无锡 214044 276974602@qq.com 
宗刚军 中国人民解放军联勤保障部队第九○四医院无锡市太湖医院,心血管内科,无锡 214044 276974602@qq.com 
葛青 中国人民解放军联勤保障部队第九○四医院无锡市太湖医院,高干病房,无锡 214044 276974602@qq.com 
施卫荣 中国人民解放军联勤保障部队第九○四医院无锡市太湖医院,高干病房,无锡 214044 276974602@qq.com 
陆晓丹 中国人民解放军联勤保障部队第九○四医院无锡市太湖医院,高干病房,无锡 214044 276974602@qq.com 
摘要点击次数: 964
全文下载次数: 2242
中文摘要:
      目的 探讨比索洛尔联合地高辛对老年慢性心力衰竭伴非阵发性心房颤动患者心功能及心肌能量代谢的影响。方法 按随机数字表法将2018年1月至2019年1月156例中国人民解放军联勤保障部队第九○四医院(无锡市太湖医院)收治的老年慢性心力衰竭伴非阵发性心房颤动患者分为2组,每组78例。2组均给予常规基础治疗,对照组在此基础上给予地高辛治疗,观察组在对照组基础上给予比索洛尔治疗,2组均治疗4周。治疗后,比较2组心室率(最大心室率、最小心室率、平均心室率)、心功能[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)及左室射血分数(LVEF)]、心肌能量代谢[N末端B型脑钠肽前体(NT-proBNP)、肌酸激酶(CK)、心肌能量消耗(MEE)]的变化及临床疗效。结果 治疗后,观察组、对照组总有效率分别为96.15%、78.21%,观察组总有效率显著高于对照组(P<0.05)。治疗后,2组最大心室率、最小心室率、平均心室率均显著下降(P<0.05),且观察组最大心室率、最小心室率、平均心室率明显低于对照组(P<0.05)。治疗后,2组LVEDD、LVESD明显降低(P<0.05),且观察组LVEDD、LVESD显著低于对照组(P<0.05)；2组LVEF明显升高(P<0.05),且观察组LVEF显著高于对照组(P<0.05)。治疗后,2组NT-proBNP、CK、MEE水平显著降低(P<0.05),且观察组NT-proBNP、CK、MEE水平明显低于对照组(P<0.05)。结论 比索洛尔联合地高辛治疗老年慢性心力衰竭伴非阵发性心房颤动疗效显著,可明显改善患者心室率,调节心肌能量代谢,提高患者心功能。
英文摘要:
      Objective To investigate the effect of bisoprolol combined with digoxin on cardiac function and myocardial energy metabolism in elderly patients with chronic heart failure and non paroxysmal atrial fibrillation.Methods One hundred and fifty-six elderly patients with chronic heart failure and non paroxysmal AF admitted to our hospital from January 2018 to January 2019 were randomly divided into two groups,78 in each group.Both groups were given routine treatment,the control group was given digoxin treatment on this basis,the observation group was given bisoprolol treatment on the basis of the control group,both groups were treated for 4 weeks.After treatment,the changes of ventricular fibrillation rate (maximum ventricular rate,minimum ventricular rate,average ventricular rate),cardiac function (LVEDd,LVESD,LVEF),myocardial energy metabolism (NT-proBNP,CK,MEE) and clinical effect were compared between the two groups.Results After treatment,the total effective rate of the observation group and the control group were 96.15% and 78.21% respectively,and the total effective rate of the observation group was significantly higher than that of the control group (P<0.05).After treatment,the maximum ventricular rate,the minimum ventricular rate and the average ventricular rate in the two groups decreased significantly (P<0.05),and the maximum ventricular rate,the minimum ventricular rate and the average ventricular rate in the observation group were significantly lower than those in the control group (P<0.05).After treatment,the levels of LVEDd and LVESD in the two groups were significantly lower (P<0.05),and the levels of LVEDd and LVESD in the observation group were significantly lower than those in the control group (P<0.05);the levels of LVEF in the two groups were significantly higher (P<0.05),and the level of LVEF in the observation group was significantly higher than that in the control group (P<0.05).After treatment,the levels of NT-proBNP,CK and mee in the two groups decreased significantly (P<0.05),and the levels of NT proBNP,CK and mee in the observation group were significantly lower than those in the control group (P<0.05).Conclusions Bisoprolol combined with digoxin is effective in the treatment of elderly patients with chronic heart failure and non paroxysmal atrial fibrillation.It can significantly improve the rate of ventricular fibrillation,regulate myocardial energy metabolism and improve the cardiac function.
查看全文     
关闭
分享按钮