| 杨俊囡,李甜甜,吴梅,顾辨辨,孙梦雯.血清炎症标志物在间质性肺病相关肺动脉高压中的临床意义[J].中国临床保健杂志,2023,26(1):119-122. |
| 血清炎症标志物在间质性肺病相关肺动脉高压中的临床意义 |
| Clinical significance of serum inflammatory markers in pulmonary hypertension associated with interstitial lung disease |
| 投稿时间：2022-06-07 |
| DOI：10.3969/J.issn.1672-6790.2023.01.026 |
| 中文关键词: 肺疾病,间质性 肺动脉高压 临床实验室技术 |
| 英文关键词: Lung diseases,interstitial Pulmonary arterial hypertension Clinical laboratory techniques 〖FL |
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| 中文摘要: |
| 目的 探讨血清炎症标志物在间质性肺病相关肺动脉高压中的临床意义。方法 回顾性分析2017年6月至2022年4月间质性肺病(ILD)患者资料,本研究共收集了non-PH组79例、ILD-PH组72例,健康对照组资料167例。根据患者是否继发肺动脉高压(PH)进一步划分为ILD-PH组与non-PH组,同时设置健康对照组。依据血常规计算出血清炎症标志物:中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、单核细胞/淋巴细胞比值(MLR)及全身免疫炎症指数(SII)的数值。比较上述指标在3组间的差异,并通过绘制ROC曲线以评价它们对ILD及继发PH的预测诊断价值。结果 结果显示NLR、PLR、SII在3组间差异有统计学意义(ILD-PH组＞non-PH组＞健康对照组)。根据ROC曲线预测ILD的发生,SII的曲线下面积最大为0.757,其次MLR曲线下面积为0.726、NLR曲线下面积为0.723。当SII最佳截断值为471.16时,其敏感度56%,特异度86%；当MLR最佳截断值为0.25时,其敏感度68%,特异度72%；当NLR最佳截断值为2.33时,其敏感度43%,特异度93%。对于预测ILD患者是否伴有PH,NLR的曲线下面积最大为0.749,其次SII曲线下面积为0.726。当NLR最佳截断值为3.25时,其敏感度61%,特异度80%。当SII最佳截断值为574.97时,其敏感度78%,特异度66%。结论 监测NLR、SII水平对预测间质性肺病及评估其是否继发肺动脉高压具有临床意义,对于疾病早期指导治疗具有参考价值。 |
| 英文摘要: |
| Objective To investigate the clinical significance of serum inflammatory markers in interstitial lung disease (ILD) related pulmonary hypertension (PH).Methods The data of patients with interstitial lung disease who met the inclusion and exclusion criteria from June 2017 to April 2022 were retrospectively analyzed.A total of 79 cases in the non-pH group,72 cases in the ILD PH group and 167 cases in the healthy control group were collected.They were divided into ILD-PH group and non-PH group according to whether they had PH,and we set up another healthy control group.Serum inflammatory markers including NLR,PLR,mLR and SII were calculated based on blood routine tests at admission.The differences of the above indexes among the three groups were investigated,and ROC curves were drawn to evaluate the predictive diagnostic value of NLR,PLR,mLR and SII in interstitial lung disease and pulmonary hypertension.Results The results showed that the differences of NLR,PLR and SII among the three groups were statistically significant(the ILD-PH group>non-PH group>healthy control group).According to the ROC curve,for predicting the occurrence of ILD,the maximum area under the curve of SII was 0.757,followed by 0.726 for mLR and 0.723 for NLR.When SII was 471.16,the sensitivity and specificity were 56% and 86%.When mLR was 0.25,its sensitivity was 68% and specificity was 72%.When NLR equals 2.33,the sensitivity is 43% and specificity is 93%.For predicting ILD patients with PH,the maximum area under the curve was 0.749 for NLR and 0.726 for SII.When THE NLR was 3.25,the sensitivity was 61% and the specificity was 80%.When SII was 574.97,the sensitivity was 78% and specificity was 66%.Conclusions Monitoring the levels of NLR and SII is of great clinical significance for early prediction of interstitial lung disease and assessment of pulmonary hypertension,which has reference value for early guidance and treatment of the disease. |
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