| 何菁,许文芳,陈能松,等.联合检测肿瘤坏死因子α和白细胞介素6对结核性胸膜炎与恶性胸腔积液的鉴别诊断价值[J].中国临床保健杂志,2023,26(5):671-673. |
| 联合检测肿瘤坏死因子α和白细胞介素6对结核性胸膜炎与恶性胸腔积液的鉴别诊断价值 |
| Differential diagnosis of tuberculous pleurisy and malignant pleural effusion by combined detection of TNF-α and IL-6 in pleural effusion |
| 投稿时间：2023-02-18 |
| DOI：10.3969/J.issn.1672-6790.2023.05.020 |
| 中文关键词: 结核,胸膜 胸腔积液,恶性 肿瘤坏死因子α 白细胞介素6 诊断,鉴别 |
| 英文关键词: Tuberculosis,pleural Pleural effusion,malignant Tumor necrosis factor-alpha Interleukin-6 Diagnosis,differential 〖FL |
| 基金项目:浙江省医药卫生科技项目(2020ky333) |
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| 中文摘要: |
| 目的 探讨肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6联合检测在鉴别诊断结核性胸膜炎、恶性胸腔积液中的应用价值。方法 选取2019年6月至2021年6月绍兴文理学院附属医院收治的127例结核性胸膜炎患者为结核性胸膜炎组,选取同期收治的80例恶性胸腔积液患者作为恶性胸腔积液组,采用酶联免疫吸附法(ELISA)检测所有入组对象血清和胸腔积液TNF-α和IL-6水平,分析TNF-α和IL-6联合检测在诊断结核性胸膜炎中的价值。结果 结核性胸膜炎组血清TNF-α、IL-6水平分别为(14.92±6.58)、(15.62±4.64)ng/L,均高于恶性胸腔积液组中的(7.86±3.74)、(10.70±3.41)ng/L(P＜0.05)；结核性胸膜炎组胸腔积液TNF-α、IL-6水平分别为(56.92±17.58)、(468.62±122.64)ng/L,均高于恶性胸腔积液组中的(36.60±15.27)、(318.78±93.51)ng/L(P＜0.05)。ROC曲线分析显示,血清TNF-α、IL-6联合检测鉴别诊断结核性胸膜炎、恶性胸腔积液AUC为0.859,胸腔积液TNF-α、IL-6联合检测鉴别诊断结核性胸膜炎、恶性胸腔积液AUC为0.924。结论 相比于血清指标,胸腔积液TNF-α、IL-6联合检测鉴别诊断结核性胸膜炎、恶性胸腔积液具有较好的应用价值。 |
| 英文摘要: |
| Objective To explore the application value of pleural fluid tumor necrosis factor-α (TNF-α) combined with interleukin-6 (IL-6) in the differential diagnosis of tuberculous pleurisy and malignant pleural effusion.Methods A total of 127 patients with tuberculous pleurisy were enrolled as tuberculous pleurisy group in Affiliated Hospital of Shaoxing University between June 2019 and June 2021,while other 80 patients with malignant pleural effusion during the same period were enrolled as malignant pleural effusion group.The levels of TNF-α and IL-6 in serum and pleural fluid in all objects were detected by enzyme-linked immunosorbent assay (ELISA).The significance of TNF-α and IL-6 in the diagnosis of tuberculous pleurisy was analyzed.Results The levels of serum TNF-α and IL-6 in tuberculous pleurisy group were (14.92±6.58) ng/L and (15.62±4.64) ng/L,higher than those in malignant pleural effusion group[(7.86±3.74) ng/L,(10.70±3.41) ng/L,P<0.05].The levels of pleural fluid TNF-α and IL-6 in tuberculous pleurisy group were (56.92±17.58) ng/L and (468.62±122.64) ng/L,higher than those in malignant pleural effusion group[(36.60±15.27) ng/L,(318.78±93.51) ng/L,P<0.05].ROC curve analysis showed that AUC of serum TNF-α combined with IL-6 in the differential diagnosis of tuberculous pleurisy and malignant pleural effusion was 0.859,and the AUC of pleural fluid TNF-α combined with IL-6 in the differential diagnosis of tuberculous pleurisy and malignant pleural effusion was 0.924.Conclusions Compared with serum indexes,application value of pleural fluid TNF-α combined with IL-6 is higher in the differential diagnosis of tuberculous pleurisy and malignant pleural effusion. |
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