| 李悦,韦新法,李冲,等.血小板聚集率、颈动脉内膜中层厚度、胱抑素C 与阻塞性睡眠呼吸暂停合并心血管疾病风险的关系[J].中国临床保健杂志,2023,26(6):743-746. |
| 血小板聚集率、颈动脉内膜中层厚度、胱抑素C 与阻塞性睡眠呼吸暂停合并心血管疾病风险的关系 |
| Relationship between platelet aggregation rate,CIMT,Cys C and risk of OSA complicated with CVD |
| 投稿时间：2023-07-14 |
| DOI：10.3969/J.issn.1672-6790.2023.06.006 |
| 中文关键词: 睡眠呼吸暂停,阻塞性 心血管疾病 血小板聚集 颈动脉内膜中膜厚度 半胱氨酸蛋白酶抑制物C |
| 英文关键词: Sleep apnea,obstructive Cardiovascular diseases Platelet aggregation Carotid intima-media thickness Cystatin C 〖FL |
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| 中文摘要: |
| 目的 探讨血小板聚集率、颈动脉内膜中层厚度(CIMT)、胱抑素C(Cys C)与阻塞性睡眠呼吸暂停(OSA)合并心血管疾病(CVD)风险的关系。方法 选取2021年3月至2023年2月在应急总医院治疗的OSA患者74例,根据是否合并CVD分为单纯OSA组(48例)和OSA合并CVD组(26例)；对比2组患者临床特征和血清中血小板聚集率、CIMT、Cys C水平；采用多因素logistic回归分析影响OSA合并CVD的独立危险因素；采用受试者工作曲线(ROC)分析血小板聚集率、CIMT、Cys C对OSA患者合并CVD的预测价值。结果 74例OSA患者中有26例发生CVD,其中:冠心病4例、高血压14例、心力衰竭5例、心律失常3例；48例患者为单纯OSA,OSA合并CVD发生率为35.14%；单纯OSA组和OSA合并CVD组患者性别、婚姻状况、文化程度、体重指数、血红蛋白、血清白蛋白、高密度脂蛋白胆固醇比较,差异均无统计学意义(P>0.05)；OSA合并CVD组60岁以上患者占比、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、血小板聚集率、CIMT及Cys C均高于单纯OSA组(P<0.05)；多因素logistic回归分析结果显示:年龄(＞60岁)、LDL-C、血小板聚集率、CIMT、Cys C均为OSA患者合并CVD的独立危险因素(P<0.05)。ROC曲线分析结果显示:血小板聚集率、CIMT及Cys C联合检测曲线下面积(AUC)为0.962,高于单独检测的0.810、0.839、0.901,且联合检测敏感度、特异度均高于单独检测。结论 年龄(＞60岁)、LDL-C、血小板聚集率、CIMT、Cys C均是OSA患者合并CVD的独立危险因素,且LDL-C、血小板聚集率、CIMT、Cys C联合检测对OSA患者合并CVD具有较高的预测效能。 |
| 英文摘要: |
| Objective To investigate the relationship between platelet aggregation,carotid intima-media thickness (CIMT),cystatin C (Cys C) and the risk of obstructive sleep apnea (OSA) complicated with cardiovascular disease (CVD).Methods Seventy-four patients with OSA treated in Emergency General Hospital from March 2021 to February 2023 were divided into simple OSA group (n=48) and OSA with CVD group (n=26) according to whether they had CVD.The clinical characteristics and serum platelet aggregation rate,CIMT and Cys C expression were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the independent risk factors of postoperative recurrence of allergic rhinitis complicated with nasal polyps.Receiver operating characteristic (ROC) curve was used to analyze the predictive value of platelet aggregation rate,CIMT and Cys C in OSA patients with CVD.Results CVD occurred in 26 of the 76 patients with OSA,of whom:there were 4 cases of coronary heart disease,14 cases of hypertension,5 cases of heart failure and 3 cases of arrhythmia48 patients were OSA only,the incidence of OSA combined with CVD was 35.14%.There were no significant differences in sex,marital status,education level,BMI,Hb,ALB,HDL-C between OSA group and OSA with CVD group (P>0.05).The percentage of patients over 60 years old,HbA1c,TC,TG,LDL-C,platelet aggregation rate,CIMT and Cys C in OSA with CVD group were higher than those in OSA group (P<0.05).Logistic multivariate analysis showed that:Age (>60 years),LDL-C,platelet aggregation rate,CIMT and Cys C were independent risk factors for CVD in OSA patients (P<0.05).ROC curve analysis showed that:the area under the curve (AUC) of platelet aggregation rate,CIMT and Cys C was 0.962,which was higher than that of 0.810,0.839 and 0.901 respectively.The sensitivity and specificity of combined detection were higher than those of single detection.Conclusions Age (>60 years),LDL-C,platelet aggregation rate,CIMT and Cys C are independent risk factors for OSA patients with CVD,and the combined detection of these indicators has high predictive power for OSA patients with CVD. |
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