| 张存泰,左培媛,高红宇.临床医生应重视老年人心脏淀粉样变的诊断与处理[J].中国临床保健杂志,2024,27(2):145-148. |
| 临床医生应重视老年人心脏淀粉样变的诊断与处理 |
| The diagnosis and management of cardiac amyloidosis in the elderly should be taken seriously for clinicians |
| 投稿时间：2024-03-13 |
| DOI：10.3969/J.issn.1672-6790.2024.02.001 |
| 中文关键词: 心脏,淀粉样变性 诊断技术,心血管 药物疗法 老年人 |
| 英文关键词: Cardiac,amyloidosis Diagnostic techniques,cardiovascular Drug therapy Aged 〖FL |
| 基金项目: |
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| 中文摘要: |
| 心脏淀粉样变(CA)是淀粉样蛋白错误折叠沉积于心肌细胞外基质所致的心脏疾病。CA好发于老年人,由于症状缺乏特异性且既往被认为是一种罕见病,老年CA患者极易被误诊和漏诊。近年来随着对该病诊断意识的提高及无创性影像学诊断方法的进步,诊断为CA的患者有所增加；治疗CA的药物研究也有重大突破,研发了多种特异性治疗药物。早期治疗可以防止淀粉样蛋白进一步沉积导致的器官损伤,从而改善老年CA患者预后。因此,临床医生应该充分了解老年CA患者的临床特征,重视老年CA的诊断及治疗。 |
| 英文摘要: |
| Cardiac amyloidosis is a disease caused by the buildup of clumps of abnormally folded protein in the cardiac extracellular matrix.Cardiac amyloidosis was previously considered a rare disease which is frequent in elderly.There are likely to be misdiagnosed of cardiac amyloidosis in elderly patients whose symptoms lack specificity.With the development of diagnostic methods and the increased sensitivity of clinicians to disease symptoms,the incidence of patients diagnosed with cardiac amyloidosis has increased in recent years.Meanwhile,many various trials of specific amyloid drugs are obtaining promising results.The early and rapid diagnosis and therapy can prevent further amyloid deposition and further end-organ damage,thereby improving the prognosis of elderly patients with cardiac amyloidosis.Therefore,it is important for clinicians to better understand the characteristics,diagnosis and treatment of the elderly patients with cardiac amyloidosis. |
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