| 王永康,叶秋怡,张思明,等.骨密度、骨代谢标志物与中老年住院患者认知功能的相关性研究[J].中国临床保健杂志,2024,27(2):157-161. |
| 骨密度、骨代谢标志物与中老年住院患者认知功能的相关性研究 |
| Association of bone mineral density,bone metabolic markers and cognitive function in middle-aged and elderly hospitalized patients |
| 投稿时间：2024-03-10 |
| DOI：10.3969/J.issn.1672-6790.2024.02.004 |
| 中文关键词: 认知功能障碍 住院病人 生物标记 骨密度 骨钙素 保护因素 |
| 英文关键词: Cognitive dysfunction Inpatients Biomarkers Bone density Osteocalcin Protective factors 〖FL |
| 基金项目:国家自然科学基金面上项目(82272512);安徽省临床医学研究转化专项(202304295107020060) |
|
| 摘要点击次数: 751 |
| 全文下载次数: 915 |
| 中文摘要: |
| 目的 探讨中老年住院患者血清骨代谢标志物、骨密度与认知功能障碍的关系,为认知功能受损患者早期发现、早期诊断提供依据。方法 选取2021年3月至2023年11月于中国科学技术大学附属第一医院(安徽省立医院)就诊的174例住院患者作为研究对象,通过简易精神状态检查表对研究对象进行认知功能评估,并分为认知功能障碍组(70例)和认知正常组(104例),分析2组患者骨密度、骨代谢标志物水平与认知功能的相关性。结果 与认知正常组相比,认知障碍组患者的受教育程度更低(P<0.05)；而2组间年龄、性别、糖尿病史、高脂血症病史、高血压病史相比,差异无统计学意义(P>0.05)。认知障碍组患者的骨钙素、Ca水平、腰椎L1骨密度T值低于认知正常组,差异均有统计学意义(P均<0.05)；骨钙素水平的升高与认知障碍的发生呈负相关(OR=0.91,P<0.01)。结论 中老年住院患者认知功能受损可能与骨钙素水平相关,较高的骨钙素是认知功能的独立保护因素。 |
| 英文摘要: |
| Objective To explore the association between serum bone metabolic markers,bone mineral density (BMD),and cognitive impairment (CI) in middle-aged and elderly hospitalized patients,and to provide a basis for early detection and diagnosis of CI patients.Methods A total of 174 hospitalized patients attending the First Affiliated Hospital of University of Science and Technology of China from March 2021 to November 2023 were enrolled in this study,Cognitive function was assessed using the Mini-Mental State Examination (MMSE).The subjects were divided into a cognitive impairment group (n=70) and a normal control group (n=104) based on their MMSE scores.Bone density measurements and bone metabolism markers were compared between the two groups,and the correlation between cognitive function and bone-related parameters was analyzed.Results Compared with the normal control group, the cognitive impairment group exhibited lower levels of education (P<0.05), while there were no statistically significant differences between the two groups in terms of age, gender, history of diabetes, hyperlipidemia, or hypertension (P>0.05). The cognitive impairment group showed statistically significant decreases in osteocalcin, calcium levels, and lumbar spine L1 bone mineral density T-score compared to the normal control group (P<0.05). Additionally, there was a negative correlation observed between elevated levels of osteocalcin and the occurrence of cognitive impairment (OR=0.91,P<0.01).Conclusions Impaired cognitive function in middle-aged and elderly hospitalized patients may be associated with osteocalcin levels,and higher osteocalcin is an independent protective factor for cognitive function. |
|
查看全文
|
| 关闭 |
|
|
|