| 崔国风,陈梦婷,姜雪勤,等.慢性阻塞性肺疾病患者衰弱状态与营养状况及肺功能的相关性分析[J].中国临床保健杂志,2024,27(2):218-222. |
| 慢性阻塞性肺疾病患者衰弱状态与营养状况及肺功能的相关性分析 |
| Analysis of frailty status in chronic obstructive pulmonary disease patients and its correlation with nutritional status and lung function |
| 投稿时间：2023-12-28 |
| DOI：10.3969/J.issn.1672-6790.2024.02.016 |
| 中文关键词: 肺疾病,慢性阻塞性 衰弱 营养不良 肺通气 生活质量 |
| 英文关键词: Pulmonary disease,chronic obstructive Frailty Malnutrition Pulmonary ventilation Quality of life 〖FL |
| 基金项目:安徽省临床医学研究转化专项(202304295107020044)；安徽医科大学临床与前期学科共建项目(2021lcxk005,2022lcxk020) |
| 作者 | 单位 | E-mail | | 崔国风 | 安徽医科大学第一附属医院, 老年呼吸与危重症医学科,合肥 230022 | 13956988552@126.com | | 陈梦婷 | 安徽医科大学第一附属医院, 老年呼吸与危重症医学科,合肥 230022 | 13956988552@126.com | | 姜雪勤 | 安徽医科大学第一附属医院, 老年呼吸与危重症医学科,合肥 230022 | 13956988552@126.com | | 徐玉菲 | 安徽医科大学第一附属医院, 老年呼吸与危重症医学科,合肥 230022 | 13956988552@126.com | | 范云珊 | 安徽医科大学第一附属医院, 临床营养科,合肥 230022 | 13956988552@126.com | | 韩晓燕 | 安徽医科大学第一附属医院, 老年呼吸与危重症医学科,合肥 230022 | 13956988552@126.com | | 范晓云 | 安徽医科大学第一附属医院, 老年呼吸与危重症医学科,合肥 230022 | 13956988552@126.com |
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| 中文摘要: |
| 目的 探讨慢性阻塞性肺疾病(COPD)患者衰弱发生现状及其与营养状况、肺功能指标的相关性。方法 选取2022年3月至2023年6月安徽医科大学第一附属医院老年呼吸与危重症医学科收治的60例COPD患者,根据FRAIL评分将患者分为衰弱组22例、非衰弱组38例,收集患者的一般资料、临床相关指标[血红蛋白、白蛋白、前白蛋白、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)等],使用生物电阻抗分析测得人体成分数据[体蛋白质含量、体矿物质含量、骨骼肌质量(SMM)、体脂百分比等],分析比较2组衰弱状态与营养状况、肺功能之间的相关性。结果 衰弱组体重指数、白蛋白、体蛋白质含量、体矿物质含量、四肢骨骼肌质量指数(ASMI)、SMM、体脂肪含量、去脂体重(FFM)、上臂肌围(AMC)、腰臀脂肪比、FEV1、FVC低于非衰弱组(P＜0.05)；衰弱组慢性阻塞性肺疾病评估测试(CAT)评分、肌少症及营养不良风险发生率均高于非衰弱组(P＜0.05)；经Spearman分析,FRAIL评分与肌少症发生率、CAT评分呈正相关性(P＜0.05),与白蛋白、体重指数、体蛋白质含量、体矿物质含量、ASMI、SMM、FFM、AMC、FEV1、FVC呈负相关性(P＜0.05)。结论 COPD患者的衰弱状态与营养状况、肺功能等指标密切相关,临床上应对COPD患者尽早进行衰弱筛查及营养状况评估,采取针对性的干预措施。 |
| 英文摘要: |
| Objective To investigate the occurrence of frailty in patients with chronic obstructive pulmonary disease and its correlations with nutritional status and pulmonary function indicators.Methods A total of 60 patients with COPD were enrolled in department of geriatric respiratory and critical care medicine of the First Affiliated Hospital of Anhui Medical University from March 2022 to June 2023.According to the FRAIL scale,the patients were divided into a frailty group (22 cases) and a non-frailty group (38 cases).The data of general information and clinical related indicators (hemoglobin,albumin,prealbumin,FEV1,FVC,etc.)、body composition (body protein content,body mineral content,SMM,percentage of body fat) were measured by Bioelectric Impedance Analysis method of the patients were collected.Analyze and compare the correlation between two groups of frailty status,nutritional status,and lung function.Results The BMI,serum ALB,body protein content,body mineral content,ASMI,SMM,BFM,FFM,AMC,and WHR in the frailty group were lower than those in the non-frailty group (P<0.05).The CAT score,the number of cases of sarcopenia,and the nutritional risk incidence rate in the frailty group were higher than those in the non-frailty group (P<0.05).Through Spearman analysis,the FRAIL score was significantly positively correlated with the incidence of sarcopenia and CAT score (P<0.05),and negatively correlated with ALB,BMI,body protein content,body mineral content,ASMI,SMM,FFM,AMC,FEV1,and FVC (P<0.05).Conclusions The frailty status of COPD patients is closely related to nutritional status,lung function,and other indicators.In clinical practice,frailty screening and nutritional status assessment should be conducted as early as possible for COPD patients,and targeted intervention measures should be adopted. |
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