| 彭冲,林小萍,陆平,等.阿司匹林对老年结直肠腺癌术后复发及出血的影响[J].中国临床保健杂志,2024,27(2):268-272. |
| 阿司匹林对老年结直肠腺癌术后复发及出血的影响 |
| Observation of the effect of aspirin on recurrence and bleeding in elderly patients with postoperative colorectal adenocarcinoma |
| 投稿时间：2024-03-01 |
| DOI：10.3969/J.issn.1672-6790.2024.02.025 |
| 中文关键词: 结直肠肿瘤 复发 出血 阿司匹林 老年人 |
| 英文关键词: Colorectal neoplasms Recurrence Hemorrhage Aspirin Aged 〖FL |
| 基金项目:上海市卫生健康委员会面上基金项目(202040436) |
|
| 摘要点击次数: 605 |
| 全文下载次数: 399 |
| 中文摘要: |
| 目的 探讨老年结直肠腺癌的术后患者长期规律服用阿司匹林对其复发和出血的影响,并分析影响患者复发的危险因素。方法 回顾性分析2013年1月至2019年10月在上海交通大学医学院附属第九人民医院手术治疗的252例老年结直肠腺癌患者病历资料。根据患者手术治疗后是否连续服用阿司匹林(100 mg/d)≥6 个月分成阿司匹林组(49例)和非阿司匹林组(203例)。比较2组患者的年龄、性别、吸烟史、饮酒史等一般资料以及手术前的血液检测结果、病理诊断、手术资料和术后2年内的复查及随访情况；分析规律服用阿司匹林≥6个月对患者2年内的复发及消化道出血的影响。结果 (1) 阿司匹林组较非阿司匹林组的术后复发率降低(P＜0.05),消化道出血的差异无统计学意义。(2)在术前发生过肠梗阻的亚组中,阿司匹林组较非阿司匹林组消化道出血并发症高,差异有统计学意义(P＜0.05)。(3)年龄偏大、TNM Ⅳ期、诊断时各种合并症≥3种、术式为姑息术、术后未化疗与老年结直肠腺癌患者术后复发的发生风险升高相关,规律服用阿司匹(100 mg/d)≥6个月与其发生风险降低相关。结论 老年结直肠腺癌的术后患者可以通过长期规律服用阿司匹林减少复发,使用的同时可能会发生消化道出血等并发症。 |
| 英文摘要: |
| Objective To explore the effects of long-term regular aspirin use on the recurrence and bleeding in elderly postoperative patients with colorectal adenocarcinoma after surgery,and to analyze the risk factors affecting patient recurrence.Methods Two hundred and fifty-two elderly patients with colorectal adenocarcinoma who underwent surgical treatment at Ninth People′s Hospital Affiliated with Shanghai Jiaotong University School of Medicine from January 2013 to October 2019 were retrospectively analyzed.Divide patients into an aspirin group (n=49) and a non aspirin group (n=203) based on whether they have been taking aspirin (100 mg/d) continuously for ≥ 6 months after surgical treatment.Compare general information such as age,gender,smoking history,and alcohol consumption history between two groups of patients,as well as preoperative blood test results,pathological diagnosis,surgical data,and follow-up and follow-up within 2 years after surgery.Analyze the impact of regularly taking aspirin for ≥ 6 months on the recurrence and gastrointestinal bleeding of patients within 2 years.Results (1) The postoperative recurrence rate of the aspirin group was lower than that of the non aspirin group (P<0.05),and there was no statistically significant difference in gastrointestinal bleeding.(2) Among the subgroups with preoperative intestinal obstruction,the aspirin group had a higher incidence of gastrointestinal bleeding complications compared to the non aspirin group,and the difference was statistically significant (P<0.05).(3) Older age,TNM stage Ⅳ,≥ 3 comorbidities at diagnosis,palliative surgery,and no chemotherapy after surgery were associated with an increased risk of postoperative recurrence in elderly patients with colorectal adenocarcinoma.Regular use of aspirin (100 mg/d) for ≥ 6 months was associated with a reduced risk of recurrence.Conclusions Postoperative patients with elderly colorectal adenocarcinoma can reduce recurrence by regularly taking aspirin for a long time.At the same time,complications such as gastrointestinal bleeding may occur. |
|
查看全文
|
| 关闭 |
|
|
|