| 郑婉群,周岱磐,季乔雪,等.乳腺癌发病与中医体质及辨证分型的相关性研究[J].中国临床保健杂志,2024,27(3):361-364. |
| 乳腺癌发病与中医体质及辨证分型的相关性研究 |
| Correlation between breast cancer incidence and traditional Chinese medicine constitution and syndrome differentiation |
| 投稿时间：2024-03-06 |
| DOI：10.3969/J.issn.1672-6790.2024.03.017 |
| 中文关键词: 乳腺肿瘤 中医体质类型 辨证分型 影响因素分析 |
| 英文关键词: Breast neoplasms Constitutional type |
| 基金项目:国家自然科学基金项目(81903994) |
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| 中文摘要: |
| 目的 探讨乳腺癌发病与中医体质及辨证分型的相关性。方法 选取2021年1月至2023年6月在安徽医科大学第一附属医院就诊的108例乳腺癌患者为观察组,另选取同期在该院进行体检的80例健康妇女为对照组。统计所有受试者的一般资料、中医体质及中医辨证分型,采用多因素logistic回归分析乳腺癌发病的危险因素,以Spearman法分析中医体质与辨证分型的相关性。结果 108例乳腺癌患者中,以气虚质(18.52%)、气郁质(16.67%)、血瘀质(13.89%)占比较高,2组间平和质、气虚质、血瘀质、气郁质分布比例比较,差异有统计学意义(P<0.05),其他体质分布比例差异无统计学意义(P>0.05)；多因素logistic回归分析结果显示,平和质为乳腺癌发病的保护因素,气虚质、气郁质为乳腺癌发病的危险因素(P<0.05)；108例乳腺癌患者中,辨证分型最多为气血亏虚证(56.48%),其后依次为肝郁痰凝证(18.52%)、冲任失调证(16.67%)、肝肾阴虚证(8.33%)；气虚质与气血亏虚证呈正相关(P<0.05)；阴虚质与肝肾阴虚证呈正相关(P<0.05)；血瘀质与冲任失调证呈正相关(P<0.05)；气郁质与肝郁痰凝证呈正相关(P<0.05)。结论 气虚质、气郁质为乳腺癌的易感体质,乳腺癌中医体质与辨证分型存在相关性,在一定程度上影响疾病证型的发生及发展。 |
| 英文摘要: |
| Objective To analyze the correlation between the incidence of breast cancer and traditional Chinese medicine (TCM) constitution and syndrome differentiation.Methods A total of 108 breast cancer patients who visited the First Affiliated Hospital of Anhui Medical University from January 2021 to June 2023 were selected as the observation group,and 80 healthy women who underwent physical examination in Anhui Medical University during the same period were selected as the control group.The general information,TCM constitution and syndrome differentiation of all subjects were recorded.Multivariate logistic regression analysis was performed to identify the risk factors for breast cancer incidence.The correlation between TCM constitution and syndrome differentiation was discussed by Spearman method.Results Among the 108 patients with breast cancer,the proportions of qi-deficiency constitution (18.52%),qi-stagnation constitution (16.67%) and blood-stasis constitution (13.89%) were higher.There were statistically significant differences in the distribution of mild constitution,qi-deficiency constitution,blood-stasis constitution and qi-stagnation constitution between the two groups (P<0.05),but there was no statistically significant difference in the distribution of other constitutions (P>0.05).Multivariate logistic regression analysis found that mild constitution was the protective factor for breast cancer.Qi-deficiency constitution and qi-stagnation constitution were the risk factors for breast cancer (P<0.05).Among the 108 patients with breast cancer,the most common syndrome type of breast cancer was deficiency of qi and blood (56.48%),followed by Liver depression and phlegm coagulation syndrome (18.52%),disharmony of thoroughfare and conception vessels (16.67%),and yin deficiency(8.33%).Qi-deficiency constitution was positively correlated with deficiency of qi and blood syndrome (P<0.05).Yin-deficiency constitution was positively correlated with liver and kidney yin deficiency syndrome (P<0.05).Blood-stasis constitution was positively correlated with disharmony of thoroughfare and conception vessels syndrome (P<0.05).Qi-stagnation constitution was positively correlated with Liver depression and phlegm coagulation syndrome (P<0.05).Conclusions Qi-deficiency constitution and qi-stagnation constitution are predisposing constitutions of breast cancer.TCM constitutions are correlated with syndrome types of breast cancer,which affect the occurrence and development of syndrome types to a certain extent. |
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