| 金海燕,杨晓丽,杨余华,等.老年急性脑梗死患者血清磷酸化tau蛋白181与激肽释放酶6的表达及对发病后睡眠障碍的预测价值[J].中国临床保健杂志,2024,27(4):475-479. |
| 老年急性脑梗死患者血清磷酸化tau蛋白181与激肽释放酶6的表达及对发病后睡眠障碍的预测价值 |
| Expression of serum phosphorylated tau protein 181 and Kallikrein 6 in elderly patients with acute cerebral infarction and its predictive value for sleep disorder after illness |
| 投稿时间：2023-10-22 |
| DOI：10.3969/J.issn.1672-6790.2024.04.010 |
| 中文关键词: 脑梗死 tau蛋白质类 激肽释放酶类 睡眠觉醒障碍 老年人 |
| 英文关键词: Brain infarction tau Proteins Kallikreins Sleep wake disorders Aged 〖FL |
| 基金项目:江苏省卫生健康委科研项目(Z2019033);江苏省南通市科研计划项目(MSZ21051) |
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| 中文摘要: |
| 目的 观察老年急性脑梗死(ACI)患者血清磷酸化tau蛋白181(P-tau-181)和激肽释放酶6(KLK6)水平变化,并探讨其与患者发病后睡眠障碍的关系。方法 选择2020年5月至2022年5月海安市人民医院收治的158例老年ACI患者作为观察对象,根据美国国立卫生研究院卒中量表(NIHSS)评分,将其分为轻度组(40例)、中度组(81例)和重度组(37例)；患者发病后根据匹兹堡睡眠质量指数(PSQI)评分,将其分为睡眠障碍组(56例)和睡眠良好组(102例)；患者血清P-tau-181和KLK6水平选择酶联免疫吸附法检测；采用logistic回归分析法对老年ACI患者发病后睡眠障碍的影响因素进行分析；采用受试者工作特征曲线分析血清P-tau-181和KLK6水平对老年ACI患者发病后睡眠障碍的诊断价值。结果 重度组ACI患者血清P-tau-181、KLK6水平显著高于轻度组和中度组(P＜0.05),中度组血清P-tau-181、KLK6水平显著高于轻度组(P＜0.05)。与睡眠良好组患者相比较,睡眠障碍组有卒中家族史、有吸烟史以及有饮酒史患者比例及血清P-tau-181、KLK6水平较高(P＜0.05)。血清P-tau-181及KLK6水平是影响老年ACI患者发病后睡眠障碍的独立危险因素(P＜0.05)。血清P-tau-181、KLK6以及两者联合诊断老年ACI患者发病后发生睡眠障碍的ROC曲线下面积分别为0.844、0.826和0.924,联合诊断效能高于单独检测(Z=2.030,P=0.042；Z=2.340,P=0.019)。结论 老年ACI患者血清中P-tau-181及KLK6高表达可能与其发病后睡眠障碍有重要联系,且两者联合预测老年ACI患者发病后睡眠障碍效能高于单独检测。 |
| 英文摘要: |
| Objective To observe the changes of serum phosphorylated tau protein 181 (P-tau-181) and Kallikrein 6 (KLK6) levels in elderly patients with acute cerebral infarction,and explore the relationship between their levels and sleep disorder after illness.Methods From May 2020 to May 2022,158 elderly patients with acute cerebral infarction accepted by Hai′an People′s Hospital were gathered as observation subjects,according to the National Institutes of Health Stroke Scale (NIHSS) score,they were grouped into mild group (40 cases),moderate group (81 cases),and severe group (37 cases);after treatment,the patients were separated into sleep disorder group (56 cases) and good sleep group (102 cases) according to the Pittsburgh Sleep Quality Index (PSQI) score;the levels of P-tau-181 and KLK6 in the serum were detected using enzyme-linked immunosorbent assay;Logistic regression analysis was applied to analyze the influencing factors of sleep disorder in elderly patients with acute cerebral infarction after treatment;receiver operating characteristic (ROC) curve was applied to analyze the diagnostic value of serum P-tau-181 and KLK6 levels for sleep disorder in elderly patients with acute cerebral infarction after treatment.Results The serum levels of P-tau-181 and KLK6 of acute cerebral infarction patients in the severe group were obviously higher than those in the mild and moderate groups (P<0.05),while the serum levels of P-tau-181 and KLK6 in the moderate group were obviously higher than those in the mild group (P<0.05).Compared with the patients in the good sleep group,the proportions of family history of stroke,smoking history and drinking history,and the serum levels of P-tau-181 and KLK6 in the sleep disorder group were obviously higher (P<0.05).Serum levels of P-tau-181 and KLK6 were independent risk factors for sleep disorder in elderly patients with acute cerebral infarction after treatment (P<0.05).The area under the receiver operating characteristic of serum P-tau-181,KLK6 and their combination in diagnosis of sleep disorder in elderly patients with acute cerebral infarction after illness was 0.844,0.826 and 0.924,respectively,the combined diagnostic efficacy was higher than those of the individual detection efficacy (Z=2.030,P=0.042;Z=2.340,P=0.019).Conclusions The high expression of P-tau-181 and KLK6 in the serum of elderly patients with acute cerebral infarction may have an important relationship with sleep disorder after illness,and both of them are more effective than one of both for sleep disorder after illness in elderly patients with acute cerebral infarction. |
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