| 杨二丽,张晶晶,朱华良,等.纤维蛋白原与白蛋白比值及CHADS2评分与冠状动脉慢性完全闭塞性病变的相关性研究[J].中国临床保健杂志,2024,27(4):520-523. |
| 纤维蛋白原与白蛋白比值及CHADS2评分与冠状动脉慢性完全闭塞性病变的相关性研究 |
| The correlation between fibrinogen to albumin ratio and CHADS2 scores with coronary chronic total occlusion |
| 投稿时间：2024-03-22 |
| DOI：10.3969/J.issn.1672-6790.2024.04.020 |
| 中文关键词: 冠心病 心血管造影术 纤维蛋白原 白蛋白类 影响因素分析 |
| 英文关键词: Coronary disease Angiocardiography Fibrinogen Albumins Root cause analysis 〖FL |
| 基金项目:安徽省高校科研项目重点项目(2022AH050770) |
| 作者 | 单位 | E-mail | | 杨二丽 | 安徽医科大学第二附属医院, 老年心血管内科,合肥 230601 | 155166971@qq.com | | 张晶晶 | 安徽医科大学第二附属医院, 老年心血管内科,合肥 230601 | 155166971@qq.com | | 朱华良 | 安徽医科大学第二附属医院, 老年心血管内科,合肥 230601 | 155166971@qq.com | | 赵宇飞 | 安徽医科大学第二附属医院, 老年心血管内科,合肥 230601 | 155166971@qq.com | | 祝小霞 | 安徽医科大学第二附属医院, 老年心血管内科,合肥 230601 | 155166971@qq.com | | 黄正 | 安徽医科大学第二附属医院,心血管内科,合肥 230601 | 155166971@qq.com |
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| 中文摘要: |
| 目的 探讨纤维蛋白原与白蛋白比值(FAR)及CHADS2评分与冠状动脉慢性完全闭塞性病变(CTO)的相关性。方法 回顾性分析2015年7月至2023年12月于安徽医科大学第二附属医院老年心血管内科行冠状动脉造影术(CAG)检查确诊的244例冠心病患者病历资料,根据CAG结果将其分为CTO组(142例)和非CTO组(102例)。根据Gensini积分取三分位数分组,将其分为低积分组(82例)、中积分组(82例)和高积分组(80例)。结果 CTO和非CTO患者间年龄、高血压、心力衰竭、脑血管事件、吸烟、血红蛋白、白蛋白、尿素氮、纤维蛋白原、FAR、CHADS2评分及Gensini积分比较,差异有统计学意义(P＜0.05)。多因素logistic回归分析结果显示,吸烟、FAR及CHADS2评分与CTO相关(P＜0.05)。各积分组患者间年龄、心力衰竭比例、吸烟比例、白蛋白、总胆固醇、纤维蛋白原、FAR、CHADS2评分及CTO比例比较,差异均有统计学意义(均P＜0.05)。Spearman相关分析显示,FAR和CHADS2评分与Gensini积分均呈正相关(P＜0.05)。结论 FAR及CHADS2评分与CTO的发生独立相关,对于患者术前冠状动脉病变严重程度的评估有一定的指导意义。 |
| 英文摘要: |
| Objective To investigate the correlation between fibrinogen to albumin ratio(FAR) and CHADS2 scores in patients with coronary chronic total occlusion(CTO).Methods Two hundred and forty-four patients who underwent coronary angiography (CAG) in the Department of Geriatric Cardiology at the Second Affiliated Hospital of Anhui Medical University from July 2015 to December 2023 were included with coronary artery angiography,which were classified into CTO (n=142) and non-CTO (n=102).The tertiles were divided into three groups according to Gensini score,including low-score group(n=82),medium-score group(n=82)and high-score group(n=80).Result The age,the incidence of hypertension,heart failure,cerebrovascularevents,smoking,hemoglobin,albumin,urea nitrogen,fibrinogen,FAR,CHADS2 scores and Gensini score were significantly different between in CTO group and non-CTO group (P<0.05).Multivariate logistic regression analysis showed that smoking,FAR and CHADS2 score were associated with CTO (P<0.05).There were significant differences in age,heart failure ratio,smoking ratio,albumin,total cholesterol,fibrinogen,FAR,CHADS2 score,and CTO ratio among different score groups (P<0.05).Correlation analysis showed that FAR and Gensini score,CHADS2 scores and Gensini score were statistically significant (P<0.05).Conclusions FAR and CHADS2 scores are independently associated with the occurrence of CTO and there is a correlation between FAR and CHADS2 scores and the severity of CTO,which have some implications for the assessment of preoperative coronary severity. |
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