| 朱通宇,宋迎婧,黄永跃.血清纤维胶凝蛋白3、胱抑素C、信号素3A与老年高血压患者颈动脉粥样硬化程度的相关性分析[J].中国临床保健杂志,2024,27(4):547-550. |
| 血清纤维胶凝蛋白3、胱抑素C、信号素3A与老年高血压患者颈动脉粥样硬化程度的相关性分析 |
| Correlation analysis of serum Ficolin-3,Cys C,Semaphorin 3A levels with the degree of carotid atherosclerosis in elderly patients with hypertension |
| 投稿时间：2024-06-11 |
| DOI：10.3969/J.issn.1672-6790.2024.04.026 |
| 中文关键词: 高血压 纤维胶凝蛋白3 半胱氨酸蛋白酶抑制物C 信号素3A 老年人 |
| 英文关键词: Hypertension Ficolin-3 Cystatin C Semaphorin-3A Aged 〖FL |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨老年高血压患者血清纤维胶凝蛋白3(Ficolin-3)、胱抑素C(Cys C)、信号素3A(Semaphorin 3A)水平变化及其与颈动脉粥样硬化程度的相关性。方法 回顾性分析2021年5月至2023年5月临海市中医院医共体收治的120例老年高血压患者病历资料,将这120例作为高血压组,根据颈动脉粥样硬化程度将其分为颈动脉内膜中层厚度(IMT)正常组(37例)、IMT增厚组(40例)和颈动脉斑块形成组(43例)。另选同期152例非高血压的老年健康体检者病历资料作为对照组。比较高血压组、对照组及不同颈动脉粥样硬化程度患者血清Ficolin-3、Cys C、Semaphorin 3A水平；采用Spearman法分析老年高血压患者血清Ficolin-3、Cys C、Semaphorin 3A水平与颈动脉粥样硬化程度的相关性；采用受试者工作特征(ROC)曲线分析血清Ficolin-3、Cys C、Semaphorin 3A水平单独及联合检测对老年颈动脉粥样硬化的诊断价值。结果 高血压组血清Ficolin-3、Semaphorin 3A水平低于对照组,而Cys C水平高于对照组(P<0.05)；颈动脉斑块形成组血清Ficolin-3、Semaphorin 3A水平均低于IMT增厚组和IMT正常组,IMT增厚组低于IMT正常组(P<0.05)；而颈动脉斑块形成组血清Cys C水平高于IMT增厚组和IMT正常组,IMT增厚组高于IMT正常组(P<0.05)。老年高血压患者血清Ficolin-3、Semaphorin 3A水平与颈动脉粥样硬化程度呈负相关(r=-0.429、r=-0.452,均P<0.05)；Cys C水平与颈动脉粥样硬化程度呈正相关(r=0.829,P<0.05)。结论 血清Ficolin-3、Semaphorin 3A在老年高血压患者中呈低表达,与患者颈动脉粥样硬化程度呈负相关；Cys C呈高表达,与患者颈动脉粥样硬化程度呈正相关。 |
| 英文摘要: |
| Objective To investigate serum fibrinogen 3(Ficolin-3),cystatin C (Cys C) and Semaphorin 3A (Semaphorin 3A) levels and their correlation with the degree of carotid atherosclerosis in elderly patients with hypertension.Method One hundred and twenty elderly patients with hypertension admitted to the Medical Community of Linhai Traditional Chinese Medicine Hospital from May 2021 to May 2023 were retrospectively selected as hypertension group.According to the degree of carotid atherosclerosis,they were divided into normal carotid intimedia thickness (IMT) group (n=37),IMT thickened group (n=40) and carotid plaque formation group (n=43).A total of 152 healthy elderly patients without hypertension were selected as control group.Serum Ficolin-3,Cys C,Semaphorin 3A levels were compared between hypertension group,control group and patients with different degrees of carotid atherosclerosis.Spearman method was used to analyze the correlation between serum Ficolin-3,Cys C,Semaphorin 3A levels and the degree of carotid atherosclerosis in elderly patients with hypertension.The diagnostic value of serum Ficolin-3,Cys C,Semaphorin 3A levels alone and combined with receiver operating characteristic curve (ROC) was analyzed.Results Serum Ficolin-3 and Semaphorin 3A levels in hypertension group were significantly lower than those in control group,but Cys C levels were significantly higher than those in control group (P<0.05).Serum Ficolin-3 and Semaphorin 3A levels in carotid artery plaque formation group were significantly lower than those in IMT thickening group and normal IMT group,and those in IMT thickening group were lower than those in normal IMT group (P<0.05).The serum Cys C level in carotid artery plaque formation group was significantly higher than that in IMT thickening group and IMT normal group,and that in IMT thickening group was higher than that in IMT normal group (P<0.05).Spearman correlation analysis showed that serum Ficolin-3 and Semaphorin 3A levels were negatively correlated with carotid atherosclerosis course in elderly patients with hypertension (r=-0.429,r=-0.452,P<0.05);Cys C level was positively correlated with carotid atherosclerosis course (r=0.829,P<0.05).Conclusions Serum levels of Ficolin-3 and Semaphorin 3A were low in elderly patients with hypertension,which were negatively correlated with the degree of carotid atherosclerosis.The high expression of Cys C was positively correlated with the degree of carotid atherosclerosis. |
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