| 李斯琪,刘岩,徐丽斯,等.2型糖尿病合并冠心病患者发生急性冠脉综合征的预测方法探讨[J].中国临床保健杂志,2024,27(5):597-601. |
| 2型糖尿病合并冠心病患者发生急性冠脉综合征的预测方法探讨 |
| Study on the prediction method of acute coronary syndrome in type 2 diabetes patients with coronary heart disease |
| 投稿时间：2024-05-29 |
| DOI：10.3969/J.issn.1672-6790.2024.05.006 |
| 中文关键词: 糖尿病,2型 冠心病 冠状动脉疾病 单核细胞 胆固醇,HDL 胆固醇,LDL |
| 英文关键词: Diabetes mellitus,type 2 Coronary disease Coronary artery disease Monocytes Cholesterol,HDL Cholesterol,LDL〖FL |
| 基金项目:国家自然科学基金面上项目(82170297) |
|
| 摘要点击次数: 307 |
| 全文下载次数: 253 |
| 中文摘要: |
| 目的 探讨血清单核细胞/高密度脂蛋白胆固醇比值(MHR)及低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值(LHR)联合检测对2型糖尿病(T2DM)合并冠心病(CAD)患者发生急性冠脉综合征(ACS)的预测价值。方法 回顾性分析2023年10—12月就诊于中国人民解放军北部战区总医院的265例T2DM-CAD患者资料,根据是否发生ACS分为ACS组、对照组,ACS包括不稳定型心绞痛、非ST段抬高性心肌梗死、ST段抬高性心肌梗死。比较2组之间的MHR、LHR,绘制受试者工作特征(ROC)曲线分析MHR联合LHR对T2DM-CAD患者发生ACS的预测价值。根据Gensini积分将ACS组分为2个亚组(轻度病变组、重度病变组),比较亚组间MHR、LHR的差异,分析MHR、LHR与Gensini积分的相关性。结果 ACS组的MHR、LHR高于对照组(P<0.05)。多因素logistic回归分析显示,MHR、LHR是T2DM-CAD患者发生ACS的危险因素。MHR预测T2DM-CAD患者发生ACS的ROC曲线下面积是0.767,LHR预测的ROC曲线下面积是0.683,两者联合预测的ROC曲线下面积为0.793。ACS组2个亚组的比较,重度病变组的MHR、LHR高于轻度病变组。Spearman相关性分析显示,MHR、LHR与Genisini积分呈正相关。结论 MHR、LHR可作为T2DM-CAD患者发生ACS的预测指标,两者联合的预测价值更优。T2DM合并ACS患者的MHR、LHR与冠脉病变程度呈正相关。 |
| 英文摘要: |
| Objective To investigate the predictive value of the serum monocyte to high-density lipoprotein cholesterol ratio (MHR) and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LHR) combined detection for predicting acute coronary syndrome (ACS) in patients with type 2 diabetes mellitus (T2DM) complicated with coronary artery disease (CAD).Methods A retrospective analysis was conducted on data of 265 T2DM-CAD patients admitted to the General Hospital of the Northern Theater Command of the People′s Liberation Army of China from October to December 2023.The patients were divided into ACS group and control group based on the occurrence of ACS,including unstable angina (UA),non-ST-segment elevation myocardial infarction (NSTEMI),and ST-segment elevation myocardial infarction (STEMI).The MHR and LHR between the two groups were compared,and receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of MHR combined with LHR for ACS in T2DM-CAD patients.The ACS group was further divided into two subgroups based on Gensini score:mild lesion group and severe lesion group.The difference in MHR and LHR between the subgroups was compared,and the correlation between MHR,LHR,and the Gensini score was analyzed.Results The MHR and LHR in the ACS group were significantly higher than those in the control group (P<0.05).Multivariable logistic regression analysis indicated that MHR and LHR were risk factors for ACS in T2DM-CAD patients.The ROC curve showed an area under the curve(AUC) of 0.767 for MHR in predicting ACS in T2DM-CAD patients,while the AUC for LHR was 0.683,and the combined AUC for both was 0.793.The MHR and LHR in the severe lesion group were significantly higher than those in the mild lesion group.Spearman correlation analysis revealed a positive correlation between MHR,LHR,and the Gensini score.Conclusions MHR and LHR can serve as predictive indicators for the occurrence of ACS in T2DM patients with CAD.The MHR and LHR in T2DM patients with ACS are positively correlated with the severity of coronary artery lesions. |
|
查看全文
|
| 关闭 |
|
|
|