| 陈婷,孔琪,王晶,等.三酰甘油与高密度脂蛋白胆固醇比值对非酒精性脂肪性肝病严重程度的预测价值[J].中国临床保健杂志,2024,27(5):631-634. |
| 三酰甘油与高密度脂蛋白胆固醇比值对非酒精性脂肪性肝病严重程度的预测价值 |
| The predictive value of the ratio of triglycerides to high-density lipoprotein cholesterol for the severity of non-alcoholic fatty liver disease |
| 投稿时间：2024-07-22 |
| DOI：10.3969/J.issn.1672-6790.2024.05.013 |
| 中文关键词: 非酒精性脂肪性肝病 三酰甘油 高密度脂蛋白胆固醇 |
| 英文关键词: Non-alcoholic fatty liver disease Triglyceride High-density lipoprotein cholesterol 〖FL |
| 基金项目:湖北省卫生健康科研基金资助项目(WJ2019H243)；湖北省孝感市自然科学计划项目(XGKJ2021010070) |
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| 中文摘要: |
| 目的 探讨三酰甘油(TG)与高密度脂蛋白胆固醇(HDL-C)的比值(TG/HDL-C)对非酒精性脂肪性肝病(NAFLD)严重程度的预测价值。方法 选取2021年6月至2022年12月在武汉科技大学附属孝感医院健康管理部进行健康体检且诊断为NAFLD患者526例,根据腹部超声检查结果,分为轻度366例、中度129例、重度31例,比较3组间一般资料、生化指标、TG/HDL-C的差异及其相关性,绘制受试者工作特征(ROC)曲线,评价TG/HDL-C对NAFLD严重程度的预测价值。结果 (1)3组间体重、体重指数(BMI)、腰围、腰臀比、收缩压、舒张压、TG、HDL-C、TG/HDL-C、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、空腹血糖(FPG)、尿酸(UA)、脂肪百分比、内脏脂肪面积比较,差异均有统计学意义(P＜0.05)。其中,与轻度NAFLD组比较,中度与重度NAFLD组体重、BMI、腰围、腰臀比、TG、TG/HDL-C、ALT、AST、脂肪百分比、内脏脂肪面积均升高,差异均有统计学意义(P＜0.05)；与中度NAFLD组比较,重度NAFLD组BMI、TG、TG/HDL-C、ALT、AST、UA升高,HDL-C降低,差异均有统计学意义(P＜0.05)。(2)TG/HDL-C与腰围、臀围、腰臀比、BMI、舒张压、TC、FPG、UA、ALT、AST、内脏脂肪面积、TG呈正相关；与HDL-C呈负相关。(3) ROC曲线显示,TG/HDL-C诊断中重度 NAFLD的截点值为1.76,灵敏度和特异度分别为0.494、0.787。结论 TG/HDL-C与NAFLD严重程度密切相关,TG/HDL-C可用于临床上NAFLD的严重程度的预测。 |
| 英文摘要: |
| Objective To explore the predictive value of triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for the severity of non-alcoholic fatty liver disease (NAFLD).Methods 526 patients diagnosed with NAFLD who underwent health examinations at the Health Management Department of Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from June 2021 to December 2022 were selected.Based on abdominal ultrasound results,they were divided into mild NAFLD group(n=366),moderate NAFLD group(n=129),and severe NAFLD group(n=31).General information,biochemical indicators,TG/HDL-C differences,and their correlations were compared among the three groups.Receiver Operating Characteristic (ROC) curves were drawn to evaluate the predictive value of TG/HDL-C for the severity of NAFLD.Results (1) The differences in body weight,BMI,waist circumference,waist hip ratio,systolic blood pressure,diastolic blood pressure,TG,HDL-C,TG/HDL-C,FPG,UA,ALT,AST,fat percentage,and visceral fat area among the three groups were statistically significant (P<0.05).Compared with the mild NAFLD group,the weight,BMI,waist circumference,waist to hip ratio,TG,TG/HDL-C,ALT,AST,fat percentage,and visceral fat area of the moderate and severe NAFLD groups were increased,and the differences were significant (P<0.05);Compared with the moderate NAFLD group,the severe NAFLD group showed a increase in BMI,TG,TG/HDL-C,ALT,AST,UA,and a decrease in HDL-C,with statistical significance (P<0.05).(2) TG/HDL-C was positively correlated with waist circumference,hip circumference,waist to hip ratio,BMI,diastolic blood pressure,TC,FPG,UA,ALT,AST,visceral fat area,and TG;There is a negative correlation with HDL-C.(3) The ROC curve showed that the cutoff value for TG/HDL-C diagnosis of moderate to severe NAFLD was 1.76,with sensitivity and specificity of 0.494 and 0.787,respectively.Conclusions TG/HDL-C is closely related to the severity of NAFLD,and TG/HDL-C can be used to predict the severity of NAFLD in clinical practice. |
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