| 朱南飞,曹云祥,刘健,等.健脾清热祛湿法治疗急性痛风性关节炎合并高脂血症的效果[J].中国临床保健杂志,2024,27(5):668-674. |
| 健脾清热祛湿法治疗急性痛风性关节炎合并高脂血症的效果 |
| Spleen-clearing,heat-clearing and dampness dissipation method for the treatment of patients with acute gouty arthritis and hyperlipidemia |
| 投稿时间：2024-03-13 |
| DOI：10.3969/J.issn.1672-6790.2024.05.022 |
| 中文关键词: 关节炎,痛风性 高脂血症 中医药疗法 细胞因子类 |
| 英文关键词: Arthritis,gouty Hyperlipidemias Traditional Chinese medicine therapy Cytokines 〖FL |
| 基金项目:国家自然科学基金面上项目(82074090)；国家中医药管理局高水平中医药重点学科建设项目(国中医药人教函〔2023〕85号)；第七批全国老中医药专家学术经验继承项目(国中医药人教函〔2022〕76号) |
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| 中文摘要: |
| 目的 观察健脾清热祛湿方联合黄芩清热除痹胶囊(HQC)治疗急性痛风性关节炎(AGA)合并高脂血症患者的临床疗效及对细胞因子的影响。方法 收集2022年1月至2023年11月就诊于安徽中医药大学第一附属医院风湿科的88例AGA合并高脂血症患者病历资料,按照有无使用健脾清热祛湿方联合HQC分为2组。对照组仅采用西医常规治疗,观察组在此基础上加用健脾清热祛湿方联合HQC,疗程均为2周。观察对照组和观察组治疗后的总有效率、视觉模拟评分法(VAS)评分、中医证候积分,检测超敏C反应蛋白(hs-CRP)、红细胞沉降率(ESR)、白细胞(WBC)、尿酸(UA)、血肌酐(SCr)、尿素氮(BUN)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-18。同时收集44例健康体检者资料设为健康组。结果 (1)治疗后,观察组有效率(95.45％,42/44)显著高于对照组(77.27％,34/44),P＜0.05。(2)治疗后,对照组和观察组的VAS评分、中医证候积分均降低,且观察组明显低于对照组(P＜0.01)。(3)与对照组相比,观察组治疗后的hs-CRP、ESR、TG、TC、LDL-C指标均较低,HDL-C明显较高(P＜0.05)。(4)与健康组相比,AGA患者的TNF-α、IL-1β、IL-18显著较高(P＜0.01)。(5)对照组和观察组治疗后,TNF-α、IL-1β、IL-18较治疗前显著较低(P＜0.01);与对照组比较,观察组TNF-α、IL-1β、IL-18指标较低(P＜0.05)。结论 健脾清热祛湿方联合HQC能够调控AGA患者的炎症因子,降低血脂、尿酸水平,控制急性期炎症,从而有效缓解关节肿痛。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of Jianpi Qingre Qushi formula combined with Huangqinqingre Chubi Capsules (HQC) in the treatment of hyperlipidemia in patients with acute gouty arthritis (AGA) and its influence on cytokines.Methods The data of 88 AGA patients with hyperlipidemia admitted to the Rheumatology Department of the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2022 to November 2023 were reviewed and collected.They were divided into two groups according to whether Jianpi Qingre Qushi formula combined with HQC was used.Control group was only treated with routine western medicine,while Observation group was additionally treated with Jianpi Qushi formula combined with HQC.The treatment course was 2 weeks.The total effective rate,VAS score and TCM syndrome score of control group and observation group before and after treatment were observed.hs-CRP,ESR,WBC,UA,SCr,BUN,TG,TC,HDL-C,LDL-C,tumor necrosis factor-α (TNF-α),interleukin (IL)-1β,interleukin-18 (IL-18) were detected.Results (1) The curative effect of observation group after treatment was 95.45%(42/44),which was significantly higher than that of control group 77.27% (34/44)(P<0.05).(2) VAS score and TCM syndrome score of both groups decreased after treatment,and the effect of observation group was better than that of control group.(P<0.01).(3) hs-CRP,ESR,TG,TC and LDL-C were significantly reduced and HDL-C significantly increased in observation group compared to control group after treatment (P<0.05).(4)TNF-α,IL-1β and IL-18 of AGA patients were significantly higher than those of healthy group (P<0.01).(5)After treatment,TNF-α,IL-1β and IL-18 in control group and observation group were significantly lower than before treatment Compared with control group,the indexes of TNF-α,IL-1β and IL-18 in observation group were lower (P<0.05).44 healthy subjects were collected.Conclusions The combination of Jianpi Qingre Qushi Formula and HQC can regulate the inflammatory factors of AGA patients,reduce their blood lipids,control acute inflammation,and effectively alleviate joint swelling and pain. |
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