| 邢燕,王炜,胡圆圆,等.三酰甘油-葡萄糖指数与酮症倾向2型糖尿病发病风险的相关性研究[J].中国临床保健杂志,2024,27(6):777-781. |
| 三酰甘油-葡萄糖指数与酮症倾向2型糖尿病发病风险的相关性研究 |
| The association between triglyceride glucose index and the risk of ketosis-prone type 2 diabetes |
| 投稿时间：2024-05-28 |
| DOI：10.3969/J.issn.1672-6790.2024.06.012 |
| 中文关键词: 糖尿病,2型 酮病 胰岛素抵抗 糖基化血红蛋白A 危险因素 |
| 英文关键词: Diabetes mellitus,type 2 Ketosis Insulin resistance Glycated hemoglobin A Risk factors 〖FL |
| 基金项目:国家自然科学基金项目(82270863)；安徽省高校自然科学研究重点项目(2023AH053411) |
| 作者 | 单位 | E-mail | | 邢燕 | 中国科学技术大学附属第一医院安徽省立医院, 内分泌科,合肥230001 | ysd196406@163.com | | 王炜 | 中国科学技术大学附属第一医院安徽省立医院, 内分泌科,合肥230001 | ysd196406@163.com | | 胡圆圆 | 中国科学技术大学附属第一医院安徽省立医院, 内分泌科,合肥230001 | ysd196406@163.com | | 崔克乐 | 中国科学技术大学附属第一医院安徽省立医院,检验科,合肥230001 | ysd196406@163.com | | 周婉 | 中国科学技术大学附属第一医院安徽省立医院, 内分泌科,合肥230001 | ysd196406@163.com | | 张梦媛 | 中国科学技术大学附属第一医院安徽省立医院,老年医学科,合肥230001 | ysd196406@163.com | | 叶山东 | 中国科学技术大学附属第一医院安徽省立医院, 内分泌科,合肥230001 | ysd196406@163.com |
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| 中文摘要: |
| 目的 探讨三酰甘油-葡萄糖(TyG)指数与酮症倾向2型糖尿病(KPD)发病的相关性。方法 回顾性分析2021年1月至2024年3月在中国科学技术大学附属第一医院(安徽省立医院)内分泌科收住的82例新诊断2型糖尿病(T2DM)患者临床资料。根据其发病时是否合并酮症,分为酮症倾向起病组(KPD组,41例)和非酮症起病组(NKPD组,41例)。收集患者的病史资料及人体测量学数据、血尿酮体、血糖、血脂、糖化血红蛋白(HbA1c)和胰岛素等指标,计算TyG指数、胰岛素抵抗指数。以TyG指数中位数值为界限将所有研究对象分为低TyG指数组和高TyG指数组,比较不同TyG的分组酮症检出率有无差异。利用二元logistic分析KPD患者起病的独立影响因素。绘制受试者工作特征(ROC)曲线确定KPD发病的预测指标。结果 KPD组TyG指数明显高于NKPD组[9.46(9.04,9.70)比9.66(9.21,11.09),Z=-2.397,P<0.05]。高TyG指数组糖尿病酮症的检出率明显高于低TyG指数组(65.0%比35.7%,χ2=7.03,P<0.05)。二元logistic回归分析显示,TyG指数和HbA1c是KPD发病的独立影响因素。对于预测糖尿病酮症倾向,TyG 指数联合HbA1c的曲线下面积为0.747(95%CI:0.641~0.852,P<0.05),当TyG指数取最佳截断值9.903时,对应的灵敏度为0.439,特异度为0.878。结论 TyG 指数升高是新诊断T2DM患者出现酮症倾向的独立危险因素；TyG指数联合HbA1c检测对KPD的发病具有较高的临床预测价值。 |
| 英文摘要: |
| Objective To investigate the correlation between triglyceride glucose index(TyG index) and the risk of ketosis-prone type 2 diabetes.Methods Eighty-two newly diagnosed T2DM patients admitted to department of endocrinology of the First Affiliated Hospital of the University of Science and Technology of China from January 2021 to March 2024 were selected.They were divided into ketosis-prone type 2 diabetes group(KPD group,n=41) and non-ketosis onset group(NKPD group,n=41).The medical history and anthropometric data,ketone body in serum and urine,glucose and lipid metabolism,pancreatic islet function and other data of the two groups were collected.TyG index and insulin resistance index were calculated and compared.Moreover,based on the median value of TyG index,all subjects were redivided into low TyG index group and high TyG index group,then the difference of the prevalence of diabetic ketosis between the two sub-groups was compared.Binary logistic analysis was used to analyze the independent risk factors of the onset of ketosis-prone type 2 diabetes.Receiver operating(ROC) curves determine predictors of development in ketosis-prone type 2 diabetes.Results The TyG index in KPD group was significantly higher than that of the NKPD group [9.46(9.04,9.70) vs 9.66(9.21,11.09),Z=-2.397,P<0.05].In addition,the incidence of diabetic ketosis in high TyG index group was significantly higher than that in low TyG index group (65.0% vs 35.7%, χ2=7.03,P<0.05).Binary logistic regression analysis showed that TyG index and HbA1c were independent risk factors for the tendency of ketosis in newly diagnosed T2DM patients.ROC curve analysis showed that the area under the curve of TyG index combined with HbA1c for predicting the tendency of diabetic ketosis was 0.747(95%CI:0.641-0.852,P<0.05).On occasion of the optimal cutoff value of TyG index was 9.903,the corresponding sensitivity was 0.439 and the specificity was 0.878.Conclusions TyG index may be an independent risk factor for the onset of ketosis-prone type 2 diabetes.TyG index combined with HbA1c detection has higher predictive value in the onset of ketosis-prone T2DM patients. |
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