| 刘岩,徐丽斯,李斯琪,等.中老年患者血浆同型半胱氨酸水平与动脉粥样硬化的相关性分析[J].中国临床保健杂志,2024,27(6):786-789. |
| 中老年患者血浆同型半胱氨酸水平与动脉粥样硬化的相关性分析 |
| Correlation between plasma homocysteine level and atherosclerosis in middle-aged and elderly patients |
| 投稿时间：2024-06-15 |
| DOI：10.3969/J.issn.1672-6790.2024.06.014 |
| 中文关键词: 高半胱氨酸 动脉粥样硬化 颈动脉内膜中膜厚度 危险因素 |
| 英文关键词: Homocysteine Atherosclerosis Carotid intima-media thickness Risk factors 〖FL |
| 基金项目:国家自然科学基金面上项目(82170297) |
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| 中文摘要: |
| 目的 分析同型半胱氨酸(Hcy)水平在动脉粥样硬化患者血浆中的表达情况,及其与动脉粥样硬化的关系。方法 回顾性分析2019年8月至2020年7月北部战区总医院体检或入院诊治的438例45~65岁患者的资料。按照颈部超声检查颈动脉内膜中层厚度(IMT)结果分为内膜正常组(A组,IMT<1.0 mm,148例),内膜增厚组(B组,1.0 mm≤IMT＜1.3 mm,141例),内膜斑块形成组(C组,IMT≥1.3 mm或斑块形成,149例)。比较3组间一般资料、患病情况、脂代谢指标和血浆Hcy水平,并分析血浆Hcy水平与动脉粥样硬化的相关性。结果 A组血浆Hcy水平低于B组、C组,差异有统计学意义(P<0.05)；B组血浆Hcy水平低于C组,差异有统计学意义(P<0.05)；血浆Hcy与动脉粥样硬化程度相关(r=0.326,P<0.05)。二元logistic回归分析显示,血浆Hcy水平、年龄等均是动脉粥样硬化的危险因素；高密度脂蛋白胆固醇水平是动脉粥样硬化的保护因素,血浆Hcy是动脉粥样硬化的独立危险因素(P<0.05,OR=1.155,95%CI:1.071~1.244)。结论 血浆Hcy水平是动脉粥样硬化的独立危险因素。对血浆 Hcy水平高的人群及时监测和早期干预,将有助于预防及延缓动脉粥样硬化发生。 |
| 英文摘要: |
| Objective To analyze plasma homocysteine (Hcy) level of patients with atherosclerosis and its rebationship with atherosclerosis middle aged and elderly patients.Methods A retrospective analysis was conducted on the medical records of 438 patients aged 45-65 who underwent physical examinations or were admitted to the General Hospital of the Northern Theater Command from August 2019 to July 2020.According to the results of the intima media thickness (IMT) of the carotid artery,the patients were divided into the normal endometrial group (Group A),IMT<1.0 mm,148 cases),endometrial thickening group (Group B,1.0 mm≤IMT<1.3 mm,141 cases)and endometrial plaque formation group (Group C,IMT≥1.3 mm or plaque formation,149 cases).The general information,morbidity,lipid metabolism index and plasma Hcy level among the three groups were analyzed and compared,and the correlation between plasma Hcy level and atherosclerosis was analyzed.Results The plasma Hcy levels in Group A were lower than that in Group B and Group C,the difference was statistically significant(P<0.05).The plasma Hcy level in Group B were lower than that in Group C,and the difference was statistically significant(P<0.05).Plasma Hcylevel was correlated with the degree of atherosclerosis(r=0.326,P<0.05).The resultof binary logistic regression analysis showed that plasma Hcy levels and age were risk factors for atherosclerosis;high-density lipoproteinlevels was a protect factor for atherosclerosis;plasma Hcy level was an independent risk factor for atherosclerosis(P<0.05,OR=1.155,95%CI:1.071-1.244).Conclusions Plasma Hcy level is an independent risk factor for atherosclerosis.Timely monitoring and early intervention for people with high plasma Hcy level will help prevent and delay atherosclerosis. |
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