| 徐菁菁,何年安,亓晓宇,等.聚桂醇与无水乙醇硬化治疗甲状腺囊肿的效果及影响因素分析[J].中国临床保健杂志,2024,27(6):799-803. |
| 聚桂醇与无水乙醇硬化治疗甲状腺囊肿的效果及影响因素分析 |
| Comparison of the therapeutic effects and analysis of influencing factors between lauromacrogol and anhydrous ethanol for thyroid cysts |
| 投稿时间：2024-06-11 |
| DOI：10.3969/J.issn.1672-6790.2024.06.017 |
| 中文关键词: 甲状腺结节 聚桂醇 乙醇 硬化疗法 危险因素 |
| 英文关键词: Thyroid nodule Lauromacrogol Ethanol Sclerotherapy Risk factors 〖FL |
| 基金项目: |
| 作者 | 单位 | E-mail | | 徐菁菁 | 中国科学技术大学附属第一医院安徽省立医院, 超声科,合肥 230001 | henianan71@qq.com | | 何年安 | 中国科学技术大学附属第一医院安徽省立医院, 超声科,合肥 230001 | henianan71@qq.com | | 亓晓宇 | 中国科学技术大学附属第一医院安徽省立医院耳鼻咽喉头颈外科,合肥 230001 | henianan71@qq.com | | 王章飞 | 中国科学技术大学附属第一医院安徽省立医院检验科,合肥 230001 | henianan71@qq.com | | 叶显俊 | 中国科学技术大学附属第一医院安徽省立医院, 超声科,合肥 230001 | henianan71@qq.com | | 蒋贤贤 | 中国科学技术大学附属第一医院安徽省立医院, 超声科,合肥 230001 | henianan71@qq.com | | 吴佩佩 | 中国科学技术大学附属第一医院安徽省立医院检验科,合肥 230001 | henianan71@qq.com | | 汪静 | 中国科学技术大学附属第一医院安徽省立医院病理科,合肥 230001 | henianan71@qq.com |
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| 中文摘要: |
| 目的 比较超声引导下聚桂醇与无水乙醇硬化治疗甲状腺囊肿的临床疗效并分析相关影响因素。方法 回顾性分析2018年5月至2023年1月在中国科学技术大学附属第一医院(安徽省立医院)治疗的73例甲状腺囊肿硬化患者病历资料。观察组36例,应用聚桂醇治疗；对照组37例,应用无水乙醇治疗。对比术中、术后疼痛与声音改变等并发症发生率以及2组患者的症状评分、美容评分、甲状腺功能改变及囊肿的体积缩小率(VRR)。结果 观察组的术中疼痛发生率(2.8%)显著低于对照组(35.1%),差异有统计学意义(P＜0.05)。术后1年内,2组的症状评分、美容评分、甲状腺功能指标、囊肿VRR比较,差异均无统计学意义(P＞0.05)。多因素 logistic 回归分析结果显示,囊液中血管内皮生长因子(VEGF)浓度是影响治疗后12个月VRR的独立危险因素(P＜0.05)。结论 聚桂醇和无水乙醇硬化治疗甲状腺囊肿均可有效地缩小囊肿体积,但聚桂醇作为硬化剂更能降低术中患者疼痛发生率。囊液中VEGF浓度是影响术后12个月VRR的独立危险因素。 |
| 英文摘要: |
| Objective To compare the clinical efficacy of ultrasound-guided lauromacrogol and anhydrous ethanol in the treatment of thyroid cysts and analyze the related influencing factors.Method A retrospective analysis was conducted on the medical records of 73 patients with thyroid cystic sclerosis treated at the First Affiliated Hospital of University of Science and Technology of China from May 2018 to January 2023.Observation group of 36 cases,treated with lauromacrogol;a control group of 37 cases were treated with anhydrous ethanol.The incidence of complications such as intraoperative and postoperative pain and sound changes,as well as the symptom scores,cosmetic scores,thyroid function changes,and cyst volume reduction rate (VRR) of two groups of patients were compared.Results The incidence of intraoperative pain in the observation group (2.8%) was significantly lower than that in the control group (35.1%),and the difference was statistically significant (P<0.05).Within one year after surgery,there was no statistically significant difference (P>0.05) in symptom scores,cosmetic scores,thyroid function indicators,and cyst VRR between the two groups.The results of multiple logistic regression analysis showed that the concentration of vascular endothelial growth factor (VEGF) in the cystic fluid was an independent risk factor affecting VRR at 12 months after treatment (P<0.05).Conclusions Both lauromacrogol and anhydrous ethanol sclerotherapy can effectively reduce the volume of thyroid cysts,but lauromacrogol as a sclerotherapy agent can better reduce the incidence of pain and complications in patients during surgery.The concentration of VEGF in the cystic fluid is an independent risk factor for VRR at 12 months after sclerotherapy. |
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