| 赵欣,孟兰,李晓玲,等.2型糖尿病合并新型冠状病毒感染住院老年患者的临床特点及预后影响因素分析[J].中国临床保健杂志,2024,27(6):804-808. |
| 2型糖尿病合并新型冠状病毒感染住院老年患者的临床特点及预后影响因素分析 |
| Clinical characteristics of hospitalized elderly patients with type 2 diabetes mellitus complicated with COVID-19 and factors of affecting prognosis |
| 投稿时间：2024-04-19 |
| DOI：10.3969/J.issn.1672-6790.2024.06.018 |
| 中文关键词: 糖尿病,2型 新型冠状病毒感染 危险因素 住院病人 老年人 |
| 英文关键词: Diabetes mellitus,type 2 COVID-19 Risk factors Inpatients Aged 〖FL |
| 基金项目:国家自然科学基金项目(82271617) |
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| 中文摘要: |
| 目的 探讨2型糖尿病合并新型冠状病毒感染的住院老年患者临床特点及预后影响因素。方法 收集2022年12月至2023年3月入住中国科学技术大学附属第一医院(安徽省立医院)的129例新型冠状病毒感染老年患者病历资料。根据是否合并2型糖尿病分为糖尿病(DM)组(70例)和非糖尿病(NDM)组(59例)。通过临床电子病历获取并分析患者的临床资料。结果 和NDM组比较,DM组患者发热,乏力,胸闷,意识障碍,高血糖,凝血功能障碍,心肌、肝、肾损伤等发生率高；DM组比NDM组两肺叶受累情况更严重,继发真菌感染比例更高,病重持续更长时间(均P＜0.05)；DM组病死率(41.43%)高于NDM组(6.78%)。多因素logistic回归分析显示,胸闷、意识障碍,真菌感染是2型糖尿病合并新型冠状病毒感染住院老年患者预后的独立危险因素。结论 2型糖尿病合并新型冠状病毒感染老年患者临床症状多样,继发感染多,炎症反应隐匿,多脏器功能障碍出现早、发生率高,病死率高；胸闷、意识障碍、真菌感染是其预后的独立危险因素。 |
| 英文摘要: |
| Objective To explore the clinical characteristics and influencing factors of type 2 diabetes mellitus on the outcome of hospitalized elderly patients with COVID-19.Methods The medical records of 129 elderly patients diagnosed with COVID-19 who were admitted to the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital) from December 2022 to March 2023 were selected.According to the presence or absence of type 2 diabetes,they were divided into diabetes (DM) group (70 cases) and non-diabetes (NDM) group (59 cases).The patient′s clinical data were obtained and analyzed through clinical electronic medical records.Results Compared with NDM group,DM group had a higher incidence of fever,fatigue,chest tightness,consciousness disorder,hyperglycemia,coagulation dysfunction,myocardial injury,liver and kidney injury.Compared with NDM group,DM group showed more severe involvement in both lobes,a higher proportion of secondary fungal infections,the duration of severe illness lasted longer (all P<0.05).The mortality rate in DM group (41.43%) was higher than that in NDM group (6.78%).Multivariate logistic regression analysis showed that chest tightness,impaired consciousness,and fungal infection were independent risk factors for the outcome of hospitalized elderly patients with type 2 diabetes mellitus and COVID-19.Conclusions Elderly patients with type 2 diabetes mellitus and COVID-19 have various clinical symptoms,many secondary infections,insidious inflammatory reactions,early onset,high incidence and high mortality of multiple organ dysfunction,which require early monitoring and management.Chest tightness,consciousness disorders,and fungal infections are independent risk factors for its prognosis. |
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