| 郑佩,薛鑫,刘霖,等.老年男性阻塞性睡眠呼吸暂停患者发生衰弱与高尿酸血症的关系[J].中国临床保健杂志,2024,27(6):809-812. |
| 老年男性阻塞性睡眠呼吸暂停患者发生衰弱与高尿酸血症的关系 |
| Research on the relationship between hyperuricemia and frailty in elderly male patients with obstructive sleep apnea |
| 投稿时间：2024-09-20 |
| DOI：10.3969/J.issn.1672-6790.2024.06.019 |
| 中文关键词: 睡眠呼吸暂停,阻塞性 高尿酸血症 衰弱 男人 老年人 |
| 英文关键词: Sleep apnea,obstructive Hyperuricemia Frailty Men Aged 〖FL |
| 基金项目:保健课题面上项目(22BJZ52,23BJZ27)；军队装备建设应用研究项目(LB20211A010013) |
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| 中文摘要: |
| 目的 探讨高尿酸血症(HUA)与老年阻塞性睡眠呼吸暂停(OSA)患者发生衰弱之间的关系。方法 选取2015年1月至2017年10月北京及甘肃6家医院睡眠中心收集诊断为OSA的716例老年男性患者病历资料。确诊高尿酸患者83例,纳入高尿酸组。将年龄、体重指数、呼吸暂停低通气指数(AHI)以及是否饮酒与高尿酸组进行匹配后筛选出来83例尿酸正常患者,纳入尿酸正常组,并使用Cox分析探究2组之间HUA与衰弱的关系。结果 与尿酸正常组比较,高尿酸组衰弱积分、三酰甘油指数、高血压患病率、肾功能不全和衰弱的患病率较高,平均氧饱和度较低,差异均有统计学意义(均P<0.05)。多因素Cox分析显示,HUA是老年男性 OSA患者发生衰弱的独立危险因素(aHR=2.626,95%CI:1.405~4.909；P=0.002)。Spearman相关分析显示,尿酸与衰弱(r=0.198,P=0.011)以及衰弱积分(r=0.337,P<0.001)显著相关。亚组分析显示,<80岁(aHR=4.992,95%CI:1.988~12.533；P=0.001)以及AHI≥30(aHR=4.384,95% CI:1.510~15.474；P=0.008)的患者,合并HUA时发生衰弱的风险更高。结论 HUA是老年男性OSA患者发生衰弱的独立危险因素；合并HUA时,<80岁或重度OSA老年患者发生衰弱的风险更高。 |
| 英文摘要: |
| Objective To explore the relationship between hyperuricemia(HUA) and the development of frailty in elderly patients with obstructive sleep apnea(OSA).Methods A total of 716 elderly male patients diagnosed with OSA were collected from 6 sleep centers in Beijing and Gansu from January 2015 to October 2017.Based on the levels of uric acid in the patients,83 patients with high uric acid were selected and defined as the high uric acid group.After matching for age,body mass index,apnea-hypopnea index(AHI),and alcohol consumption,83 patients with normal uric acid levels were selected and defined as the normal uric acid group.Cox survival analysis was used to explore the relationship between hyperuricemia and frailty.Results Compared with the normal uric acid group,the high uric acid group had a higher frailty score,triglycerides and and a higher incidence of hypertension,renal insufficiency,and frailty,and a lower mean pulse oxygen saturation,with statistically significant differences(P<0.05).Multivariate Cox analysis showed that HUA(aHR=2.626,95%CI:1.405-4.909；P=0.002) was an independent risk factor for frailty in elderly male OSA patients.Spearman correlation analysis showed that uric acid was significantly correlated with frailty(r=0.198,P=0.011) and frailty score(r=0.337,P<0.001).Subgroup analysis showed that patients less than 80 years old(aHR=4.992,95%CI:1.988-12.533；P=0.001) and patients with AHI≥30(aHR=4.384,95% CI:1.501~15.474；P=0.008) had a higher risk of frailty when combined with HUA.Conclusions HUA is an independent risk factor for frailty in elderly male OSA patients.When merging HUA,elderly patients under 80 years old or with severe OSA have a higher risk of frailty. |
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