| 徐畅,陈辉珍,叶仕炬,等.中性粒细胞与淋巴细胞比值在重症肺炎患者中的动态变化及对预后的评估价值[J].中国临床保健杂志,2024,27(6):813-817. |
| 中性粒细胞与淋巴细胞比值在重症肺炎患者中的动态变化及对预后的评估价值 |
| The prognostic role of the neutrophil-to-lymphocyte ratio in patients with severe pneumonia |
| 投稿时间：2024-03-05 |
| DOI：10.3969/J.issn.1672-6790.2024.06.020 |
| 中文关键词: 中性粒细胞 淋巴细胞 肺炎 危险因素 预后 |
| 英文关键词: Neutrophil Lymphocytes Pneumonia Risk factors Prognosis 〖FL |
| 基金项目:国家自然科学基金青年项目(82000224) |
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| 中文摘要: |
| 目的 研究重症肺炎患者血清中性粒细胞与淋巴细胞比值(NLR)动态变化趋势对预后的预测价值。方法 回顾性收集2021年1月至2023年7月期间入住杭州市中医院武林院区ICU病房的重症肺炎患者病历资料,收集患者基本资料及其第1、2、3、5天的全血细胞检测结果,计算得到NLR、淋巴细胞与单核细胞比值(LMR)。根据28 d结局,将患者分为生存组与死亡组。使用二元logistic回归分析独立危险因素,绘制ROC曲线分析独立危险因素对预后的预测价值。第1、2、3、5天NLR预测重症肺炎患者死亡的ROC曲线下面积分别为0.847、0.855、0.879、0.954。结果 死亡组患者在入住的前5天,NLR呈波动上升趋势,且均高于生存组；LMR则持续低于生存组。二元logistic回归分析显示,第1、2、3、5天的NLR和第1、2、5天的LMR是影响患者28 d全因死亡的独立危险因素,NLR对重症肺炎患者28 d死亡有较好的预测价值。结论 对于重症肺炎患者,NLR、LMR是预估死亡的重要指标。 |
| 英文摘要: |
| Objective To investigate the value of Neutrophil-to-Lymphocyte in predicting the prognosis of patients with severe pneumonia.Methods From January 2021 to July 2023,patients with severe pneumonia were included in Department of Intensive Care Unit in Hangzhou Hospital of Traditional Chinese Medicine.Basic clinical data and biomarkers at day 1,2,3 and 5 were collected to calculate NLR and LMR.According to the outcome of day 28,the patients were divided into survival group and death group.Logistic regression was conducted to analyze independent risk factors,and ROC was conducted to analyze the predictive value of independent risk factors to prognosis.On day 1,2,3 and 5,the AUC of ROC curve for mortality predicted by the NLR was 0.847,0.855,0.879,and 0.954.Results The NLR of the death group patients showed a fluctuating upward trend 5 days before admission,and was higher than that of the survival group;LMR remained consistently lower than the survival group.Binary logistic regression analysis showed that NLR on day 1,2,3,and 5,as well as LMR on day 1,2,and 5,were independent risk factors for all-cause mortality in patients at day 28.NLR had good predictive value for day 28 mortality in patients with severe pneumonia.Conclusion Among patients with severe pneumonia,NLR and LMR are usefur indexes in predecting the death of such patients. |
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