| 李昕逸,陆守荣,宋承雅,等.老年2型糖尿病合并骨质疏松症危险因素的研究进展[J].中国临床保健杂志,2024,27(6):849-854. |
| 老年2型糖尿病合并骨质疏松症危险因素的研究进展 |
| Research progress on risk factors of elderly type 2 diabetes mellitus with osteoporosis |
| 投稿时间：2024-07-03 |
| DOI：10.3969/J.issn.1672-6790.2024.06.027 |
| 中文关键词: 糖尿病,2型 骨质疏松 危险因素 老年人 综述 |
| 英文关键词: Diabetes mellitus,type 2 Osteoporosis Risk factors Aged Review 〖FL |
| 基金项目:南京医科大学无锡医学中心专病队列项目(WMCC202311) |
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| 中文摘要: |
| 骨质疏松症是2型糖尿病在骨骼系统的常见并发症,主要表现为骨量下降、骨质结构破坏。老年2型糖尿病患者合并骨质疏松症与多种因素有关。现有研究显示,骨质疏松发生风险增加主要与增龄、性激素水平降低、长期高血糖状态、胰岛素缺乏、胰岛素样生长因子1减少、长期高血脂、炎症细胞因子增多、低体重指数、糖尿病微血管病变、某些降糖药等因素有关。该文就国内外关于老年2型糖尿病合并骨质疏松症危险因素的最新进展进行综述,旨在为下一步研究及临床工作提供参考。 |
| 英文摘要: |
| Osteoporosis is a common complication of type 2 diabetes mellitus (T2DM) in the skeletal system,which is mainly manifested as decreased bone mass and destruction of bone structure.The elderly patients with T2DM complicated with osteoporosis are related to many factors.Existing researches indicate that the increased risk of osteoporosis is primarily related to aging,decreased sex hormones,long-term hyperglycemia,insulin deficiency,reduced IGF-1,long-term hyperlipidemia,increased inflammatory cytokines,low BMI,diabetic microangiopathy and certain hypoglycemic agents.This article provides a review of the latest advancements in research on the risk factors of osteoporosis in elderly patients with T2DM,both domestically and internationally,in order to provide references for future research and clinical practice. |
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