| 李娇娇,王秋梅.老年人营养状态与认知功能的相关性分析[J].中国临床保健杂志,2025,28(1):67-71. |
| 老年人营养状态与认知功能的相关性分析 |
| Correlation analysis between nutritional status and cognitive function in elderly people |
| 投稿时间：2024-12-07 |
| DOI：10.3969/J.issn.1672-6790.2025.01.012 |
| 中文关键词: 认知功能障碍 营养不良 衰弱 危险因素 老年人 |
| 英文关键词: Cognitive dysfunction Malnutrition Frailty Risk factors Aged 〖FL |
| 基金项目:国家重点研发计划项目(2022YFF1100400) |
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| 摘要点击次数: 85 |
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| 中文摘要: |
| 目的 探讨老年人营养与认知功能之间的相关性。方法 回顾性分析2016年9月至2019年6月北京协和医院老年科住院患者临床资料,应用简易智力状态量表评估认知功能,Fried衰弱量表评估衰弱状态,营养评估使用微营养评估量表简表(MNA-SF)；并收集患者营养相关生化指标,包括血红蛋白、白蛋白、前白蛋白、维生素B12和叶酸等。结果 共纳入425例老年患者,中位年龄76岁；其中认知功能正常且强壮者294例(69.2%),仅衰弱者31例(7.3%),仅认知障碍者77例(18.1%),认知障碍且衰弱者23例(5.4%)。单因素分析显示,各组间的营养相关生化指标差异无统计学意义(P＞0.05),但营养状态评估有明显差异(P＜0.01)。上述4组的MNA-SF评分中位值分别为12、11、10和7分,营养不良的发生率分别为36.8%、56.0%、71.4%和81.8%,其中认知障碍且衰弱组老年人MNA-SF评分最低,营养不良发生率最高。二元逻辑回归分析显示,调整年龄、疾病负担后,营养状态评分与仅认知障碍(OR=0.84,95%CI:0.78~0.91)、仅衰弱(OR=0.79,95%CI:0.71~0.89)和认知障碍且衰弱(OR=0.71,95% CI:0.62~0.80)独立相关,且有统计学意义(均P＜0.001)。结论 独立于衰弱,老年人营养状态与认知功能相关。 |
| 英文摘要: |
| Objective To explore the association between nutrition and cognitive function.Methods A retrospective analysis was conducted among inpatients in the Department of Geriatrics of Peking Union Medical College Hospital from September 2016 to June 2019.Cognitive function was assessed by using the Mini-Mental State Examination,frailty status was evaluated with the Fried Frailty Phenotype,and nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF).Additionally,nutrition-related biochemical indicators including hemoglobin,albumin,prealbumin,vitamin B12,and folate were collected.Results A total of 425 elderly patients were included,with a median age of 76 years;among them,294 (69.2%) were in the normal and strong cognitive function group,31 (7.3%) were frail only,77 (18.1%) had cognitive impairment only,and 23 (5.4%) had both frailty and cognitive impairment (cognitive frailty).Univariate analysis revealed no differences in nutrition-related biochemical indicators among the groups (P＞0.05),but significant differences in nutritional status assessments(P＜0.01).The median MNA-SF scores for the four groups were 12,11,10,and 7 points,respectively;the incidence of malnutrition was 36.8%,56.0%,71.4%,and 81.8%,respectively.The cognitive frailty group had the lowest MNA-SF scores and the highest incidence of malnutrition.Binary logistic regression analysis showed that nutritional status scores were independently associated with only cognitive impairment (OR=0.84,95%CI:0.78-0.91),only frailty (OR=0.79,95%CI:0.71-0.89),and cognitive impairment and frailty (OR=0.71,95%CI:0.62-0.80),with statistical significance (all P<0.001) after adjusting for age and disease burden.Conclusion Independent of frailty,nutritional status in the elderly is associated with cognitive impairment. |
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