| 崔延飞,吉英杰,卿松,等.肝硬化患者合并肌少症的危险因素分析[J].中国临床保健杂志,2025,28(2):181-185. |
| 肝硬化患者合并肌少症的危险因素分析 |
| The risk factors of patients with liver cirrhosis complicated with sarcopenia |
| 投稿时间：2024-12-12 |
| DOI：10.3969/J.issn.1672-6790.2025.02.006 |
| 中文关键词: 肝硬化 肌减少症 胃肠出血 血清白蛋白 危险因素 |
| 英文关键词: Liver cirrhosis Sarcopenia Gastrointestinal hemorrhage Serum albumin Risk factors 〖FL |
| 基金项目:国家老年疾病临床医学研究中心资助项目(NCRCG-PLAGH-2024015)；军队保健“十四五”规划重要保健对象感染性疾病诊疗基地建设项目(2022) |
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| 中文摘要: |
| 目的 探讨肝硬化患者合并肌少症的临床特征及危险因素。方法 回顾性分析2023年2月至2024年1月在中国人民解放军总医院第五医学中心老年医学科住院的122例肝硬化患者临床资料,收集基本信息、生化指标以及四肢骨骼肌质量指数。依据骨骼肌质量指数(ASMI)将患者分为肌少症组(40例)和无肌少症组(82例),进一步采用多因素 logistic 回归分析筛选肝硬化合并肌少症的风险因素。结果 肝硬化合并肌少症的发生率为32.7%；与非肌少症组相比,肝硬化合并肌少症患者的体重较轻、年龄较大,合并糖尿病、消化道出血的比例较高,血白蛋白、红细胞计数、血红蛋白、谷丙转氨酶、胆碱酯酶、钙离子水平较低,差异均有统计学意义(均P<0.05)；多因素logistic回归分析显示,较低的血清白蛋白水平(OR=0.785,95%CI:0.652~0.945,P=0.011)及合并消化道出血(OR=264.059,95%CI:6.495~10 735.586,P=0.003)是肝硬化患者发生肌少症的独立危险因素。结论 合并消化道出血、血清白蛋白降低是肝硬化患者发生肌少症的主要危险因素。 |
| 英文摘要: |
| Objective To explore the clinical characteristics and risk factors of patients with cirrhosis complicated by sarcopenia.Methods The clinical data of 122 patients with liver cirrhosis hospitalized in the Department of Geriatrics of the Fifth Medical Center,General Hospital of the People′s Liberation Army from February 2023 to January 2024 were retrospectively analyzed,Basic information,biochemical indicators and limb skeletal muscle mass index were collected.According to the skeletal muscle mass index (ASMI),the patients were divided into sarcopenia group (40 cases) and non sarcopenia group (82 cases),Multivariate logistic regression analysis was further used to screen the risk factors of liver cirrhosis complicated with sarcopenia.Results The incidence of cirrhosis with sarcopenia was 32.7%.Compared with the non sarcopenia group,the weight of patients with cirrhosis complicated with sarcopenia was lower (P<0.05),the proportion of older patients with diabetes mellitus and gastrointestinal bleeding was significantly higher (P<0.05).the levels of albumin,red blood cell count,hemoglobin,alanine transferase,cholinesterase and calcium ion were lower (P<0.05).Multivariate logistic regression analysis showed that lower albumin level (OR=0.785,95%CI:0.652-0.945,P=0.011) and combined gastrointestinal bleeding (OR=264.059,95%CI:6.495-10 735.586,P=0.003) were independent risk factors for sarcopenia in patients with liver cirrhosis.Conclusions The decrease of serum albumin is an important risk factor for sarcopenia in patients with cirrhosis complicated with gastrointestinal bleeding. |
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