| 宋雨,刘盼,潘一鸣,等.血浆动脉硬化指数与老年人肌少症的相关性研究[J].中国临床保健杂志,2025,28(2):191-195. |
| 血浆动脉硬化指数与老年人肌少症的相关性研究 |
| Association of atherogenic index of plasma with sarcopenia in older adults |
| 投稿时间：2025-03-27 |
| DOI：10.3969/J.issn.1672-6790.2025.02.008 |
| 中文关键词: 肌减少症 血管硬化程度 胆固醇,HDL 脂代谢障碍 危险因素 老年人 |
| 英文关键词: Sarcopenia Vascular stiffness Cholesterol, HDL Lipid metabolism disorders Risk factors Aged 〖FL |
| 基金项目:国家重点研发计划项目(2023YFC3603404)；北京市属医学科研院所公益发展改革试点项目(JYY2023-13)；首都医科大学宣武医院国自然青年培育项目(QNPY2022017) |
| 作者 | 单位 | E-mail | | 宋雨 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | sykyle@126.com | | 刘盼 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | | | 潘一鸣 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | | | 张亚欣 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | | | 陈雨濛 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | | | 李静 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | | | 马丽娜 | 首都医科大学宣武医院老年医学科,国家老年疾病临床医学研究中心,北京100053 | |
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| 中文摘要: |
| 目的 探讨血浆动脉硬化指数(AIP)与老年人肌少症的关联性。方法 该研究采用横断面设计,连续纳入2021年4月至2023年12月于首都医科大学宣武医院老年医学科住院的1 055例年龄≥60岁的患者。对患者进行肌少症评估,根据评估结果分为肌少症组(153例)和非肌少症组(902例)。检测三酰甘油和高密度脂蛋白胆固醇水平并计算AIP。采用多因素logistic回归分析评估AIP与肌少症的关联,并进行相关性分析。结果 肌少症组的AIP(-0.12±0.28)显著低于非肌少症组(0.09±0.28),P<0.001。多因素logistic回归分析显示,较高的AIP水平与较低的肌少症风险独立相关。相关性分析显示,AIP与四肢骨骼肌质量(r=0.239,P<0.001)、相对骨骼肌质量指数(r=0.260,P<0.001)及握力(r=0.111,P<0.001)均呈正相关。结论 老年住院患者中,较高的AIP与较低的肌少症风险独立相关,提示脂代谢可能在肌少症的病理生理过程中发挥作用。 |
| 英文摘要: |
| Objective To investigate the association between atherogenic index of plasma (AIP) and sarcopenia in elderly inpatients.Methods This cross-sectional study consecutively enrolled 1 055 patients aged ≥60 years hospitalized in the department of geriatric medicine,Xuanwu Hospital,Capital Medical University,from April 2021 to December 2023.They were subsequently categorized into the sarcopenia group (n=153) and the non-sarcopenia group (n=902).Triglyceride and high-density lipoprotein cholesterol levels were measured,and AIP was calculated.Multivariate logistic regression analysis was used to evaluate the association between AIP and sarcopenia,with subgroup and correlation analyses also performed.Results The AIP level in sarcopenia group (-0.12±0.28) was significantly lower than that in non-sarcopenia groupvs (0.09±0.28),P<0.001.Multivariate logistic regression analysis revealed that a higher AIP level was independently associated with a lower risk of sarcopenia.Correlation analysis showed a positive correlation between AIP and appendicular skeletal muscle mass (r=0.239,P<0.001),relative skeletal muscle mass index (r=0.260,P<0.001),and handgrip strength (r=0.111,P<0.001).Conclusions In elderly inpatients,a higher AIP level is independently associated with a lower risk of sarcopenia,suggesting that lipid metabolic disturbances may play a role in the pathophysiology of sarcopenia. |
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