| 徐天宏,叶珊,苏兵强,等.老年血管性痴呆患者血清神经丝蛋白轻链、β-淀粉样蛋白42、β-淀粉样蛋白40、磷酸化的tau蛋白水平表达及其临床意义[J].中国临床保健杂志,2025,28(2):248-252. |
| 老年血管性痴呆患者血清神经丝蛋白轻链、β-淀粉样蛋白42、β-淀粉样蛋白40、磷酸化的tau蛋白水平表达及其临床意义 |
| Expression and clinical significance of serum NFL,Aβ42,Aβ40 and P-tau in elderly patients with vascular dementia |
| 投稿时间：2025-01-05 |
| DOI：10.3969/J.issn.1672-6790.2025.02.020 |
| 中文关键词: 痴呆,血管性 血清学试验 神经微丝蛋白质类 淀粉样β肽类 老年人 |
| 英文关键词: Dementia,vascular Serologic tests Neurofilament proteins Amyloid beta-peptides Aged 〖FL |
| 基金项目:浙江省金华市科技计划项目(2020-4-062) |
|
| 摘要点击次数: 29 |
| 全文下载次数: 26 |
| 中文摘要: |
| 目的 研究老年血管性痴呆(VD)患者血清神经丝蛋白轻链(NFL)、β-淀粉样蛋白(Aβ)42、Aβ40、磷酸化的tau蛋白(P-tau)水平表达及其临床意义。方法 回顾性收集2020年1月至2022年12月在金华市第二医院诊治的80例缺血性脑卒中患者临床资料。根据患者常规治疗3个月后复诊时是否发生VD分为观察组(发生VD,25例)和对照组(未发生VD,55例)。收集患者临床资料,通过多因素logistic回归方程分析缺血性脑卒中患者继发VD的影响因素；借助受试者工作特征(ROC)曲线分析VD患者血清NFL、Aβ42、Aβ40、P-tau的表达临床意义。结果 观察组大梗死比例及发病时血清总胆固醇(TC)、三酰甘油(TG)、超敏C反应蛋白(hs-CRP)、D-二聚体、同型半胱氨酸(Hcy)、血肌酐(SCr)、NFL、Aβ42、Aβ40、P-tau水平均高于对照组(P<0.05),简易精神状态量表评分及血清高密度脂蛋白胆固醇水平低于对照组(P<0.05)；经多因素logistic回归分析显示,病灶为大梗死以及hs-CRP、Hcy、NFL、Aβ42、Aβ40、P-tau水平升高均为缺血性脑卒中患者继发VD的独立危险因素(P<0.05)；经ROC曲线分析显示,血清NFL、Aβ42、Aβ40、P-tau对VD均具有一定诊断效能,且以血清NFL的曲线下面积(AUC)最高,诊断效能相对最好(P<0.05)。结论 缺血性脑卒中患者病灶大以及血清hs-CRP、Hcy、NFL、Aβ42、Aβ40、P-tau水平越高,患者发生VD的风险越高,而NFL、Aβ42、Aβ40、P-tau血清表达水平对于VD的发生具有重要预测作用,可作为VD诊断潜在血清标志物。 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of serum neurofilament light chain (NFL),β-amyloid (Aβ) 42,Aβ40 and P-tau in elderly patients with vascular dementia (VD).Methods The medical records of 80 patients with ischemic stroke who were treated in Jinhua Second Hospital from January 2020 to December 2022 were collected retrospectively.The patients were divided into observation group (VD,n=25) and control group (non-VD,n=55) according to whether VD occurred at subsequent visit after 3 months of conventional treatment.Their clinical data were collected,and logistic regression analysis was performed to screen the influencing factors of secondary VD in patients with ischemic stroke.Receiver operating characteristic (ROC) curves were used to analyze the significance of serum NFL,Aβ42,Aβ40 and P-tau in patients with VD.Results The proportion of large infarction,serum total cholesterol (TC),triacylglycerol (TG),high-sensitivity C-reactive protein (hs-CRP),D-dimer,homocysteine (Hcy),serum creatinine (SCr),NFL,Aβ42,Aβ40 and P-tau levels in the observation group were higher than those in the control group(P<0.05).MMSE scores and serum HDL-c level were lower than those in the control group (P<0.05).Logistic regression analysis showed that large infarction,hs-CRP,Hcy,NFL,Aβ42,Aβ40,and P-tau were independent risk factors for secondary VD in patients with ischemic stroke (P<0.05).ROC curves indicated that serum NFL,Aβ42,Aβ40 and P-tau all were helpful for diagnosing VD,and the area under the curve (AUC) of serum NFL was the largest,indicating the best diagnostic efficacy (P<0.05).Conclusions The larger the infarction and the higher the serum levels of hs-CRP,Hcy,NFL,Aβ42,Aβ40 and P-tau,the higher the risk of VD in patients with ischemic stroke.Serum NFL,Aβ42,Aβ40 and P-tau levels are very helpful for predicting the occurrence of VD,and can serve as potential serum biomarkers for VD diagnosis. |
|
查看全文
|
| 关闭 |
|
|
|