| 武秀华,周荣伟,张云娇,等.三维能谱数字断层合成成像在慢性阻塞性肺疾病患者早期筛查中的诊断效能评估[J].中国临床保健杂志,2025,28(3):350-352. |
| 三维能谱数字断层合成成像在慢性阻塞性肺疾病患者早期筛查中的诊断效能评估 |
| Clinical evaluation of three-dimensional spectral digital radiography in early-stage chronic obstructive pulmonary disease screening |
| 投稿时间：2025-04-17 |
| DOI：10.3969/J.issn.1672-6790.2025.03.013 |
| 中文关键词: 肺疾病,慢性阻塞性 放射摄影术 成像,三维 诊断技术,呼吸系统 |
| 英文关键词: Pulmonary disease,chronic obstructive Radiography Imaging,three-dimensional Diagnostic techniques,respiratory system 〖FL |
| 基金项目:上海市卫生健康委员会科研项目(202040374) |
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| 中文摘要: |
| 目的 评估三维能谱数字放射成像(3D-SDR)在早期慢性阻塞性肺疾病(COPD)患者中应用的可行性和临床应用价值,为COPD早期筛查提供新的技术。方法 采用前瞻性、自身对照的单中心设计。纳入2020年6月至2023年5月上海市第六人民医院就诊的198例早期COPD患者。所有受试者接受高分辨率CT(HRCT)和3D-SDR检查,影像结果由3位资深的胸肺放射科医师独立盲法评估。结果 在HRCT阴性的136例患者中,3D-SDR阴性率为97.1%(132/136)；在HRCT阳性的62例患者中,3D-SDR阳性率为80.6%(50/62)。Pearson χ2检验显示2种影像学方法显著相关(χ2=129.64,r=0.809,P<0.001),Cohen kappa系数为0.805(P<0.001),提示诊断一致性较高。3D-SDR与HRCT的诊断早期COPD检出率分别为27.3%(54/198)和31.3%(62/198),提示两者均适用于早期筛查,HRCT的敏感性更优。结论 3D-SDR作为新的影像学检测手段,在COPD早期筛查中具有一定的临床价值,可作为COPD高风险人群的初步筛查方法。 |
| 英文摘要: |
| Objective To evaluate the feasibility and clinical application value of three-dimensional spectral digital radiography (3D-SDR) in patients with early-stage chronic obstructive pulmonary disease (COPD),and to provide a new technique for early COPD screening.Methods This study adopted a prospective,self-controlled,single-center design and enrolled 198 early-stage COPD patients who visited Shanghai Sixth People′s Hospital between June 2020 and May 2023.All participants underwent both high-resolution computed tomography (HRCT) and 3D-SDR examinations.The imaging results were independently and blindly evaluated by three senior thoracic radiologists.Results Among 136 patients with HRCT negative results,the 3D-SDR negative rate was 97.1% (132/136);among the 62 patients with HRCT positivity,the 3D-SDR positivity rate was 80.6% (50/62).The Pearson chi square test showed a significant correlation between the two imaging methods (χ2=129.64, r=0.809, P<0.001),with a Cohen kappa coefficient of 0.805 (P<0.001),indicating high diagnostic consistency.The detection rates of early COPD by 3D-SDR and HRCT were 27.3% (54/198) and 31.3% (62/198),respectively, indicating that both are suitable for early screening and HRCT has better sensitivity.Conclusions As a novel imaging detection method,3D-SDR exhibits certain clinical value in the early screening of COPD and can serve as a preliminary screening tool for high-risk COPD populations. |
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