| 王晓娜,姜晓宇,孙娜,等.不同肾功能状态人群血尿酸水平与饮食蛋白质摄入的关系[J].中国临床保健杂志,2025,28(3):353-357. |
| 不同肾功能状态人群血尿酸水平与饮食蛋白质摄入的关系 |
| The relationship between blood uric acid levels and dietary protein intake in populations with different renal function states |
| 投稿时间：2024-07-05 |
| DOI：10.3969/J.issn.1672-6790.2025.03.014 |
| 中文关键词: 尿酸 蛋白质类 高尿酸血症 肾功能不全,慢性 膳食疗法 |
| 英文关键词: Uric acid Proteins Hyperuricemia Renal insufficiency,Chronic Diet therapy 〖FL |
| 基金项目:山东中医药科技项目(Z-2023062T)；齐鲁中医药中医肾病专科集群建设项目(鲁卫函〔2023〕126号) |
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| 中文摘要: |
| 目的 探讨不同肾功能状态人群血尿酸水平与饮食蛋白质摄入的关系。方法 研究数据来源于2009年中国健康与营养调查,截至目前,仅2009年版进行了血液样本的检查。收集了有膳食调查记录和血尿酸、血肌酐检测的对象。膳食调查采用24 h膳食回顾询问法,回顾连续3 d的膳食摄入情况。使用多元回归模型与亚组分析来研究蛋白质摄入和血尿酸之间的关系。广义相加模型确定两者之间是否存在非线性关联,利用递归策略计算拐点。结果 共有8 008名受试者纳入分析,年龄中位数51岁。充分调整变量后显示,蛋白质摄入与血尿酸呈正相关(β=0.26,95%CI:0.11~0.40,P=0.001)。按肾功能分层的多元回归分析,充分调整变量后显示,肾功能正常组[估算肾小球滤过率(eGFR)>60 mL·min-1·1.73 m-2]饮食蛋白质摄入与血清尿酸呈正相关(β=0.20,95%CI:0.05~0.35,P=0.009),肾功能不全组(eGFR ≤ 60 mL·min-1·1.73 m-2)蛋白质摄入与血清尿酸不相关(β=0.47,95%CI:-0.02~0.96,P=0.062)。进一步应用两段式线性回归模型分析总体人群饮食蛋白摄入与血尿酸关系的拐点,拟合曲线拐点为92.89 g/d,在拐点之前呈正相关关系(β=0.40,95%CI:0.23~0.58,P<0.001),在拐点之后无相关性(β=-0.13,95%CI:-0.42~0.15,P=0.360)。结论 中国成人饮食蛋白质摄入量与血尿酸呈正相关,较低的膳食蛋白质摄入可能对高尿酸血症的预防和治疗有效；对于肾功能下降者,饮食蛋白质摄入与血尿酸水平无相关性。 |
| 英文摘要: |
| Objective To investigate the relationship between dietary protein intake and hyperuricemia in Chinese adult patients with or without renal dysfunction.Methods The data for this study was sourced from the 2009 China Health and Nutrition Survey.So far,only the 2009 edition has conducted blood sample testing.Collect subjects with dietary survey records and blood uric acid and creatinine tests according to the inclusion and exclusion standards.The dietary survey adopts a 24-hour dietary review inquiry method to review the dietary intake for three consecutive days.Multiple regression models and subgroup analysis were used to study the relationship between dietary protein intake and serum uric acid.The generalized additive model determines whether there is a nonlinear correlation between the two and a recursive strategy was used to calculate the inflection point.Results The study included a total of 8 008 participants with a median age of 51 years.After fully adjusting for variables,protein intake was positively correlated with serum hyperuricemia (β=0.26,95%CI :0.11-0.40,P=0.001).In the multiple regression analysis stratified by renal function,after adjusting for variables,the dietary protein intake of the normal renal function group (eGFR>60 mL·min-1·1.73m-2) was positively correlated with serum uric acid(β=0.20,95%CI:0.05-0.35,P=0.009).The relationship between protein intake and serum uric acid in the renal insufficiency group is not statistically significant (eGFR<60 mL·min-1·1.73m-2),β=0.47,95%CI:-0.02-0.96,P=0.062.Further apply a two-stage linear regression model to analyze the inflection point of the relationship between dietary protein intake and serum uric acid in individuals.Using a recursive strategy,calculate the inflection point as 92.89 g/d,before the inflection point (β=0.40,95%CI:0.23-0.58,P<0.001),and after the inflection point (β=-0.13,95%CI:-0.42-0.15,P=0.360).Conclusions Lower dietary protein intake may be effective in preventing and treating hyperuricemia,but no significant correlation has been observed between dietary protein intake and blood uric acid in individuals with renal dysfunction. |
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