| 蒋松松,孔祥勇,冯子安,等.皮肤胆固醇水平在冠心病诊断中的价值[J].中国临床保健杂志,2025,28(3):377-381. |
| 皮肤胆固醇水平在冠心病诊断中的价值 |
| The value of skin cholesterol levels in the diagnosis of coronary heart disease |
| 投稿时间：2025-04-02 |
| DOI：10.3969/J.issn.1672-6790.2025.03.019 |
| 中文关键词: 冠心病 胆固醇,皮肤 颈动脉狭窄 诊断技术,心血管 危险因素 |
| 英文关键词: Coronary disease Cholesterol,cutaneous Carotid stenosis Diagnostic techniques,cardiovascular Risk factors 〖FL |
| 基金项目:安徽省卫生健康委员会科研项目(AHWJ2022b051) |
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| 中文摘要: |
| 目的 探讨皮肤胆固醇的水平在诊断冠心病方面的价值。方法 回顾性分析2020年3月至2024年6月因胸闷或胸痛症状疑似诊断冠心病入住安徽医科大学附属省立医院的208例患者临床资料。根据冠脉造影结果分为冠心病组、非冠心病组。分析2组患者的一般临床资料、皮肤胆固醇水平、颈动脉彩色多普勒超声结果,对皮肤胆固醇水平与颈动脉斑块长度相关性进行分析。采用多因素logistic回归分析冠状动脉疾病的危险因素,并利用受试者工作特征(ROC)曲线来评估不同指标诊断冠心病的价值。结果 非冠心病组(0.25±0.07)与冠心病组(0.69±0.04)的皮肤胆固醇水平比较,差异有统计学意义(P<0.001)。单支(0.50±0.02)、双支(0.70±0.09)及三支冠状动脉病变组(0.86±0.07)患者的皮肤胆固醇水平比较,差异有统计学意义(P<0.05)。非冠心病组[(3.65±0.07)mm]与冠心病组[(10.85±1.49)mm]患者的颈动脉最大斑块长度比较,差异有统计学意义(P<0.001)。单支[(5.35±1.08)mm]、双支[(7.22±1.43)mm]及三支冠脉病变组[(8.72±1.44)mm]患者的颈动脉最大斑块长度比较,差异有统计学意义(P<0.05)。皮肤胆固醇水平与颈动脉最大斑块长度呈正相关(r=0.385,P<0.001)。多因素logistic回归分析显示,皮肤胆固醇水平(OR=2.12,P<0.001)、颈动脉最大斑块长度(OR=1.53,P<0.001)均为冠心病的预测因素。皮肤胆固醇、颈动脉最大斑块长度预测冠心病的曲线下面积(AUC)分别为0.800、0.721,灵敏度分别为73.4%、57.5%,特异度分别为77.5%、74.2%。结论 皮肤胆固醇的测定对冠心病具有较高的诊断价值。 |
| 英文摘要: |
| Objective To explore the value of skin cholesterol levels in diagnosing coronary heart disease by comparing the results of ultrasound detection of the maximum plaque length in the carotid artery.Methods The clinical data of 208 patients admitted to Anhui Medical University Affiliated Provincial Hospital from March 2020 to June 2024 with suspected diagnosis of coronary heart disease due to chest tightness or chest pain symptoms was analyzed.According to the results of coronary angiography,they were divided into coronary heart disease group and non coronary heart disease group.Analyze the general clinical data,skin cholesterol levels,and carotid artery color Doppler ultrasound results of two groups,and analyze the correlation between skin cholesterol levels and the maximum plaque length of the carotid artery.Multiple logistic regression analysis was used to identify risk factors for coronary artery disease,and utilizing receiver operating characteristic (ROC) curves to evaluate the diagnostic value of different factors for coronary heart disease.Results The difference in skin cholesterol levels between the non coronary heart disease group (0.25±0.07) and the coronary heart disease group (0.69±0.04) was statistically significant (P<0.001).The comparison of skin cholesterol levels among single vessel (0.50±0.02),double vessel (0.70±0.09),and triple vessel coronary artery disease groups (0.86±0.07) showed statistically significant differences (P<0.05).The difference in the maximum plaque length of the carotid artery between the non coronary heart disease group[(3.65±0.07) mm]and the coronary heart disease group[(10.85±1.49) mm]was statistically significant (P<0.001).There was a statistically significant difference (P<0.05) in the maximum plaque length of the carotid artery among the single vessel[(5.35±1.08) mm],double vessel[(7.22±1.43) mm],and triple vessel coronary artery disease groups[(8.72±1.44) mm].The level of skin cholesterol is positively correlated with the maximum plaque length of the carotid artery (r=0.385,P<0.001).Multivariate logistic regression analysis showed that skin cholesterol levels (OR=2.12,P<0.001) and maximum carotid plaque length (OR=1.53,P<0.001) were both predictive factors for coronary heart disease.The area under the curve (AUC) values for predicting coronary heart disease based on skin cholesterol and maximum plaque length of carotid artery were 0.800 and 0.721,respectively.The sensitivity was 73.4% and 57.5%,and the specificity was 77.5% and 74.2%,respectively.Conclusion The determination of skin cholesterol has high diagnostic value for coronary heart disease. |
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