| 金永梅,李慧云,李欣玲,等.孕早期体重指数及三酰甘油葡萄糖指数对妊娠糖尿病的预测价值[J].中国临床保健杂志,2025,28(3):394-398. |
| 孕早期体重指数及三酰甘油葡萄糖指数对妊娠糖尿病的预测价值 |
| The predictive significance of early pregnancy body mass index and triglyceride-glucose index for gestational diabetes mellitus |
| 投稿时间：2025-04-10 |
| DOI：10.3969/J.issn.1672-6790.2025.03.023 |
| 中文关键词: 糖尿病,妊娠 人体质量指数 甘油三酯类 血糖 危险因素 预测 |
| 英文关键词: Diabetes, gestational Body mass index Triglycerides Blood glucose Risk factors Forecasting 〖FL |
| 基金项目:安徽省联合共建学科重点实验室开放课题(2023ZPLH08) |
| 作者 | 单位 | E-mail | | 金永梅 | 安徽医科大学妇幼医学中心,安徽医科大学第五临床学院,安徽省妇女儿童医学中心,合肥市妇幼保健院产科,合肥 230001 | jym199803@163.com | | 李慧云 | 安徽医科大学妇幼医学中心,安徽医科大学第五临床学院,安徽省妇女儿童医学中心,合肥市妇幼保健院产科,合肥 230001 | | | 李欣玲 | 安徽医科大学妇幼医学中心,安徽医科大学第五临床学院,安徽省妇女儿童医学中心,合肥市妇幼保健院产科,合肥 230001 | | | 纪芳 | 安徽医科大学妇幼医学中心,安徽医科大学第五临床学院,安徽省妇女儿童医学中心,合肥市妇幼保健院产科,合肥 230001 | | | 蒋晓敏 | 安徽医科大学妇幼医学中心,安徽医科大学第五临床学院,安徽省妇女儿童医学中心,合肥市妇幼保健院产科,合肥 230001 | skyxiaomin@163.com |
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| 中文摘要: |
| 目的 探讨孕早期体重指数(BMI)及三酰甘油-葡萄糖(TyG)指数用于预测妊娠糖尿病(GDM)的临床价值。方法 选取2022年6月至2023年12月于合肥市妇幼保健院进行早期产前检查并住院分娩的1 019例孕妇临床资料,收集孕早期血脂检测结果及孕中期75 g口服葡萄糖耐量试验(OGTT)结果,并根据OGTT结果分为妊娠糖尿病组(GDM组)189例、非妊娠糖尿病组(非GDM组)830例；分析孕早期BMI及TyG指数对发生GDM的预测价值。结果 GDM组预产年龄≥35岁、经产妇及孕早期BMI≥24 kg/m2的孕妇占比均多于非GDM组,差异均有统计学意义(均P＜0.05)。GDM组孕妇的总胆固醇、三酰甘油、低密度脂蛋白胆固醇、空腹血糖及孕早期TyG指数均高于非GDM组,差异均有统计学意义(均P＜0.05)。二元logistic回归分析显示:≥24 kg/m2孕妇发生GDM的OR为1.719(95%CI:1.146~2.578,P＜0.01),孕早期TyG指数发生GDM的OR为10.379(95%CI:6.594~16.339,P＜0.01)。孕早期BMI联合TyG指数预测GDM发生的ROC曲线下面积(AUC为0.794,95%CI:0.758~0.829,P＜0.01)。结论 孕早期BMI及TyG指数是发生GDM的独立危险因素,孕早期BMI联合TyG指数对GDM的发生具有一定的预测价值。 |
| 英文摘要: |
| Objective To explore the clinical value of body mass index (BMI) and triacylglycerol glucose (TyG) index in early pregnancy in predicting gestational diabetes (GDM).Methods The clinical data of 1 019 pregnant women who underwent early prenatal examination and hospital delivery in Hefei Maternal and Child Health Hospital from June 2022 to December 2023 were analyzed.The results of blood lipid examination in the first trimester and 75 g oral glucose tolerance test (OGTT) in the second trimester were collected.According to the OGTT results,189 pregnant women with diabetes (GDM group) and 830 non-pregnant women with diabetes (non-GDM group) were divided into two groups.Analyze the predictive value of BMI and TyG index in early pregnancy for the occurrence of GDM.Results The proportion of pregnant women with gestational age ≥35 years,multiparous women,and early pregnancy BMI ≥24 kg/m2 in the GDM group was higher than that in the non-GDM group,and the differences were statistically significant (all P<0.05).The total cholesterol,triglyceride,low-density lipoprotein cholesterol,fasting plasma glucose and early pregnancy TyG index of pregnant women in the GDM group were higher than those in the non-GDM group,and the differences were statistically significant (all P<0.05).Binary logistic regression analysis showed that the OR for GDM in pregnant women with ≥24 kg/m2 was 1.719 (95%CI:1.146-2.578,P<0.01),and the OR for GDM in early pregnancy with TyG index was 10.379 (95%CI:6.594-16.339,P<0.01).The ROC curve results showed that the area under the curve of BMI combined with TyG index in early pregnancy predicted the occurrence of GDM (AUC=0.794,95%CI:0.758-0.829,P<0.01).Conclusions BMI and TyG index in early pregnancy are independent risk factors for the occurrence of GDM,and the combination of BMI and TyG index in early pregnancy has certain predictive value for the occurrence of GDM. |
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