| 郑丽,彭旭东,杨楚萌,等.1990年至2021年中国唇和口腔癌的疾病负担及其危险因素分析[J].中国临床保健杂志,2025,28(4):508-513. |
| 1990年至2021年中国唇和口腔癌的疾病负担及其危险因素分析 |
| Analysis of disease burden and risk factors of lip and oral cavity cancer in China from 1990 to 2021 |
| 投稿时间：2025-05-13 |
| DOI：10.3969/J.issn.1672-6790.2025.04.014 |
| 中文关键词: 唇肿瘤 口腔肿瘤 患病代价 发病率 患病率 死亡率 危险因素 |
| 英文关键词: Lip neoplasms Mouth neoplasms Cost of illness Incidence Prevalence Mortality Risk factors |
| 基金项目:军队后勤科研项目(20BJZ47);首都卫生发展科研专项(首发2022-3-6111) |
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| 中文摘要: |
| 目的 分析1990—2021年中国唇和口腔癌的疾病负担及其危险因素,量化发病率、死亡率的变化,并探讨不同性别和年龄组的差异。方法 研究数据源自全球疾病负担(GBD)2021年数据库,涵盖1990—2021年中国唇和口腔癌的发病人数、死亡人数、年龄标准化发病率(ASIR)和年龄标准化死亡率(ASMR)。运用Joinpoint 4.0.1.0软件计算年度变化百分比(APC)和平均年度变化百分比(AAPC),量化疾病负担,并对危险因素进行描述性分析。结果 1990—2021年,中国唇和口腔癌发病人数增长283.7%,ASIR上升57.6%；死亡人数增加142.3%,ASMR下降5.7%。男性发病和死亡增长幅度显著高于女性,2021年男性ASIR较1990年增长81.1%,ASMR增长9.8%。Joinpoint回归模型显示,全人群和男性ASIR呈持续上升趋势,AAPC分别为1.45%和1.94%；ASMR在全人群和男性中呈现先降后升再降的复杂趋势,女性ASMR持续下降,AAPC为-1.41%。发病和死亡高峰年龄从1990年的55~59岁推迟至2021年的65~69岁和70~74岁。吸烟、饮酒是主要危险因素,且男性受其影响更为严重。结论 1990—2021年中国唇和口腔癌疾病负担显著增加,男性和老年人群是主要高风险群体；吸烟、饮酒在疾病发生发展中起重要作用。 |
| 英文摘要: |
| Objective To analyze the disease burden of lip and oral cavity cancer and its risk factors in China from 1990 to 2021,quantify trends in incidence and mortality rates,and explore differences across genders and age groups,providing a scientific basis for targeted prevention and control strategies.Methods Data were derived from the Global Burden of Disease (GBD) 2021 database,covering the number of new cases,deaths,age-standardized incidence rate (ASIR),and age-standardized mortality rate (ASMR) of lip and oral cavity cancer in China from 1990 to 2021.Joinpoint 4.0.1.0 software was used to calculate the annual percent change (APC) and average annual percent change (AAPC) to quantify disease burden trends.Descriptive analysis of risk factors was performed.Results From 1990 to 2021,the number of lip and oral cavity cancer cases in China increased by 283.7%,with ASIR rising by 57.6%.Deaths increased by 142.3%,while ASMR decreased by 5.7%.Males experienced significantly higher increases in incidence and mortality than females;in 2021,male ASIR increased by 81.1% compared to 1990,and ASMR rose by 9.8%.Joinpoint regression revealed a sustained upward trend in ASIR for the overall population and males (AAPC=1.45% and 1.94%,respectively).ASMR for the overall population and males exhibited a complex "decline-rise-decline" pattern,whereas female ASMR consistently decreased (AAPC=-1.41%).The peak age of incidence and mortality shifted from 55-59 years in 1990 to 65-69 and 70-74 years in 2021.Smoking,alcohol use,and risk behaviors were the primary risk factors,respectively,with males disproportionately affected.Conclusions The disease burden of lip and oral cavity cancer in China increases markedly from 1990 to 2021,with males and older adults being high-risk populations.Smoking,alcohol use,and related risk behaviors play critical roles in disease progression. |
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