| 李旺,盛须仁,尹若成,等.盐酸米托蒽醌示踪剂在全甲状腺切除术治疗分化型甲状腺癌中的应用效果[J].中国临床保健杂志,2025,28(5):636-639. |
| 盐酸米托蒽醌示踪剂在全甲状腺切除术治疗分化型甲状腺癌中的应用效果 |
| Clinical study on the application efficacy of mitoxantrone hydrochloride tracer in total thyroidectomy for differentiated thyroid cancer |
| 投稿时间：2025-04-03 |
| DOI：10.3969/J.issn.1672-6790.2025.05.010 |
| 中文关键词: 甲状腺切除术 甲状腺肿瘤 米托蒽醌 放射性示踪剂 DOI:10.3969/J.issn.1672-6790.2025.05.010Clinical study on the application efficacy of mitoxantrone hydrochloride tracer in total thyroidectomy for differentiated thyroid cancer LI Wang,SHENG Xuren,YIN Ruocheng,ZHENG Xucai,GAO Yuan,ZHOU Jing |
| 英文关键词: Thyroidectomy Thyroid Neoplasms Mitoxantrone Radioactive tracers 〖FL |
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| 中文摘要: |
| 目的 探讨盐酸米托蒽醌示踪剂在全甲状腺切除术治疗分化型甲状腺癌(DTC)患者中应用的临床效果。方法 前瞻性对照研究。选取2022年9月至2023年3月在中国科学技术大学附属第一医院西区(安徽省肿瘤医院)甲状腺外科接受全甲状腺切除+双侧中央区淋巴结清扫术的120例DTC患者,术前采用随机数字表法分组,术中使用盐酸米托蒽醌示踪剂者为观察组(60例)和未使用盐酸米托蒽醌示踪剂者为对照组(60例)。对比2组患者的性别、年龄、原发灶最长径、TNM分期、被膜浸润、癌双侧分布、手术方式、淋巴结清扫数、癌转移性淋巴结清扫数目以及术前、术后甲状旁腺激素(PTH)及血钙值和术后并发症等指标。结果 2组患者性别、年龄、原发灶最长径、TNM分期、被膜浸润、癌双侧分布、手术方式等比较,差异无统计学意义(均P>0.05)。观察组淋巴结清扫数目[(15.47±4.90)枚]多于对照组[(9.07±4.00)枚],P<0.05。2组癌转移性淋巴结清扫数目差异无统计学意义(P>0.05)。观察组术后3 d的PTH及血钙值均高于对照组(P<0.05)。2组患者术后1个月PTH及血钙值比较,差异均无统计学意义(均P>0.05)。术后观察组3例出现一过性低血钙症状,对照组有11例,2组间差异有统计学意义(P<0.05)。术后1年随访,观察组恢复情况总得分低于对照组(P<0.05)。结论 分化型甲状腺癌在盐酸米托蒽醌示踪剂下行全甲状腺切除术可显著增加淋巴结清扫数目,减轻甲状旁腺损伤程度。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of mitoxantrone hydrochloride tracer in total thyroidectomy for patients with differentiated thyroid cancer(DTC).Methods A total of 120 patients with DTC who underwent total thyroidectomy and bilateral central compartment lymph node dissection at the Thyroid Surgery Department of West branch of the first Affiliated Hospital of University of Science and Technology of China (Anhui Cancer Hospital) from September 2022 to March 2023 were selected.They were grouped using a random number table method.The observation group (60 cases) included patients who received mitoxantrone hydrochloride tracer during the operation,while the control group (60 cases) included patients who did not receive mitoxantrone hydrochloride tracer.The following indicators were compared between the two groups:gender,age,maximum diameter of the primary tumor,tumor-node-metastasis (TNM) staging,capsular invasion,bilateral cancer distribution,surgical procedure,number of lymph nodes dissected,lymph node metastasis,preoperative and postoperative parathyroid hormone (PTH) and serum calcium levels,and postoperative complications.Results No statistically significant differences were found between the two groups in gender,age,maximum diameter of the primary tumor,TNM stage,capsular invasion,bilateral tumor distribution,or surgical approach (all P>0.05).The observation group had significantly more lymph nodes dissected (15.47±4.90) than the control group (9.07±4.00),P<0.05.There was no significant difference in the number of metastatic lymph nodes dissected between the groups (P>0.05).At 3 days postoperatively,PTH and serum calcium levels in the observation group were significantly higher than those in the control group (P<0.05),but no significant difference was observed at 1 month postoperatively (P>0.05).Transient hypocalcemia occurred in 3 cases in the observation group and 11 cases in the control group,with a statistically significant difference (P<0.05).At the 1-year follow-up,the overall recovery score of the observation group was significantly lower than that of the control group (P<0.05).Conclusions The use of mitoxantrone hydrochloride tracer during total thyroidectomy for differentiated thyroid cancer can significantly increase the number of lymph nodes dissected and reduce the rate of parathyroid injury. |
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