| 王慧,曹云祥,刘健,等.三维超声心动图联合血管内皮生长因子评估类风湿关节炎患者心功能的应用价值[J].中国临床保健杂志,2025,28(5):644-647. |
| 三维超声心动图联合血管内皮生长因子评估类风湿关节炎患者心功能的应用价值 |
| Study on the clinical value of three-dimensional echocardiography combined with vascular endothelial growth factor in evaluating cardiac function in patients with rheumatoid arthritis |
| 投稿时间：2025-04-17 |
| DOI：10.3969/J.issn.1672-6790.2025.05.012 |
| 中文关键词: 超声心动描记术 血管内皮生长因子类 关节炎,类风湿 心脏 功能状态 |
| 英文关键词: Echocardiography Vascular endothelial growth factors Arthritis,rheumatoid Heart Functional status 〖FL |
| 基金项目:国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023100)；安徽省卫生健康科研重点项目(AHWJ2024Aa10021)；安徽中医药大学临床科研项目(2024YFYLCZX43) |
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| 中文摘要: |
| 目的 探讨三维超声心动图与血管内皮生长因子(VEGF)在类风湿关节炎(RA)患者心功能评估中的应用价值。方法 回顾性分析2021年6月至2022年3月安徽中医药大学第一附属医院风湿免疫科收治的80例住院患者病历资料。将患者分为RA组40例、非RA组40例。对所有患者进行三维超声心动图检查、VEGF以及其他临床指标检测。对比2组患者的左心室舒张末期内径(LVDd)、左心室射血分数 (LVEF)、二尖瓣口舒张早期血流峰值速度(E)、二尖瓣口舒张晚期血流峰值速度(A)、二尖瓣口舒张早期与晚期血流峰值速度比值(E/A)和心搏出量(SV)以及血管内皮生长因子(VEGF)、红细胞沉降率(ESR)、C反应蛋白(CRP), α1-酸性糖蛋白(α1-AGP)、类风湿因子(RF)、尿酸(UA)和抗环瓜氨酸肽抗体 (CCP)的差异,并分析RA患者中VEGF、CRP、RF等指标与心功能之间的关系。结果 (1)2组患者心功能参数比较,差异无统计学意义(P＞0.05)。(2)与非RA组相比,RA组患者的血VEGF[204.61(78.85,357.12)ng/L比119.16(55.98,244.90)ng/L]、CRP[7.39(2.36,23.04)g/mL比5.01(1.48,12.82)g/mL]、RF[126.10(34.58,294.95)U/mL比5.45(3.13,9.73)U/mL]和CCP[89.80(17.55,205.50)U/mL比1.20(0.90,1.30)U/mL]、α1-AGP[107.00(78.75,138.50)g/L比82.00(65.50,116.50)g/L]、ESR[27.00(14.75,49.00)mm/1 h比18.00(11.00,39.50) mm/1 h]等指标的水平更高,但UA[250.00(199.25,275.75)μmol/L比338.50(251.50,439.25) μmol/L]的水平更低(P＜0.05)。(3)VEGF、CRP、RF、α1-AGP和ESR与心脏彩色多普勒超声中的E峰值呈负相关(P＜0.05)；CRP、RF、α1-AGP和ESR与E/A比值呈负相关(P＜0.05)。结论 VEGF及炎症指标水平升高与RA患者心功能异常相关,三维超声心动图联合VEGF检测有助于早期识别RA患者心功能异常。 |
| 英文摘要: |
| Objective To explore the value of three-dimensional echocardiography combined with vascular endothelial growth factor (VEGF) in evaluating cardiac dysfunction in patients with rheumatoid arthritis (RA).Methods The medical records of 80 inpatients from the Department of Rheumatology and Immunology at the First Affiliated Hospital of Anhui University of Chinese Medicine between June 2021 and March 2022 were collected.According to the diagnostic criteria for RA,the patients were divided into two groups:the RA group (40 cases) and the non-RA group (40 cases).All patients underwent three-dimensional echocardiography,VEGF level measurement,and clinical indicator testing.The cardiac function parameters—LVDd,LVEF,E,A,E/A,and SV—as well as clinical indicators such as VEGF,ESR,CRP,α1-AGP,RF,UA,and CCP—were compared between the two groups.The relationship between VEGF,CRP,RF,and other indicators and cardiac function in RA patients was also analyzed.Results (1) There was no statistically significant difference in cardiac function parameters between the two groups (P>0.05).(2) Compared with the non-RA group,the RA group had significantly higher levels of VEGF [204.61 (78.85,357.12) ng/L vs 119.16 (55.98,244.90) ng/L],CRP [7.39 (2.36,23.04) g/mL vs 5.01 (1.48,12.82) g/mL],RF [126.10 (34.58,294.95) U/mL vs 5.45 (3.13,9.73) U/mL],CCP [89.80 (17.55,205.50) U/mL vs 1.20 (0.90,1.30) U/mL],α1-AGP [107.00 (78.75,138.50) g/L vs 82.00 (65.50,116.50) g/L],and ESR [27.00 (14.75,49.00) mm/1 h vs 18.00 (11.00,39.50) mm/1 h],but a lower level of UA [250.00 (199.25,275.75) μmol/L vs 338.50 (251.50,439.25) μmol/L] (P < 0.05).(3) VEGF,CRP,RF,α1-AGP,and ESR were negatively correlated with the E peak in cardiac color Doppler ultrasound (P<0.05);CRP,RF,α1-AGP,and ESR were negatively correlated with the E/A ratio (P<0.05).Conclusions Elevated levels of VEGF and inflammatory markers are associated with impaired cardiac function in RA patients.The combination of three-dimensional echocardiography and VEGF detection may facilitate early identification of cardiac abnormalities. |
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