| 于岚,张永怡,黄雷,等.术前应用人血白蛋白对老年单纯胰十二指肠切除术后结局的影响[J].中国临床保健杂志,2025,28(5):688-692. |
| 术前应用人血白蛋白对老年单纯胰十二指肠切除术后结局的影响 |
| Impact of preoperative human albumin administration on postoperative outcomes in elderly patients undergoing pancreaticoduodenectomy based on propensity score matching |
| 投稿时间：2025-04-02 |
| DOI：10.3969/J.issn.1672-6790.2025.05.021 |
| 中文关键词: 胰十二指肠切除术 血清白蛋白,人 手术后并发症 老年人 |
| 英文关键词: Pancreaticoduodenectomy Serum albumin,human Postoperative complications Aged 〖FL |
| 基金项目: |
| 作者 | 单位 | E-mail | | 于岚 | 上海交通大学医学院附属瑞金医院,老年医学中心,上海 200025
上海交通大学医学院附属瑞金医院,老年病科,上海 200025 | zyy20756@rjh.com.cn | | 张永怡 | 上海交通大学医学院附属瑞金医院,老年医学中心,上海 200025
上海交通大学医学院附属瑞金医院,老年病科,上海 200025 | zyy20756@rjh.com.cn | | 黄雷 | 上海交通大学医学院附属瑞金医院,老年医学中心,上海 200025 | zyy20756@rjh.com.cn | | 万歆 | 上海交通大学医学院附属瑞金医院,计算机中心,上海 200025 | zyy20756@rjh.com.cn | | 姜胜耀 | 上海交通大学医学院附属瑞金医院,计算机中心,上海 200025 | zyy20756@rjh.com.cn | | 唐思静 | 上海交通大学医学院附属瑞金医院,老年医学中心,上海 200025 | zyy20756@rjh.com.cn | | 张俊 | 上海交通大学医学院附属瑞金医院,老年医学中心,上海 200025
上海交通大学医学院附属瑞金医院,肿瘤科,上海 200025 | zyy20756@rjh.com.cn |
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| 中文摘要: |
| 目的 探讨术前应用人血白蛋白(HA)对老年单纯胰十二指肠切除术(PD)术后结局的影响。方法 回顾性分析2016年1月至2020年12月在上海交通大学医学院附属瑞金医院行单纯PD的351例≥65岁老年患者的临床资料。应用倾向性评分法分析术前使用HA(HA组)与术前不使用HA(非HA组)的临床效果及术后结局。结果 倾向性匹配评分法成果配对56对(112例患者),年龄65~91(70.6±4.8)岁；匹配后的2组临床基线特征比较,差异无统计学意义(P＞0.05)；HA组与非HA组在手术时间、术中出血量、术后住院天数、总住院天数及住院费用比较,差异无统计学意义(P＞0.05)；术后总并发症发生严重程度、常见并发症胰瘘、胆瘘、出血、感染发生率比较,差异也无统计学意义(P＞0.05)。2组患者血清白蛋白存在时间效应,但2组间差异无统计学意义,也无交互效应,且2组血清白蛋白变化比较,差异无统计学意义(P＞0.05)。结论 老年患者行单纯胰十二指肠切除术前使用HA并不能减少术中出血量、缩短手术时间和住院时长,也不能减少术后并发症的发生,对术后白蛋白的恢复也无影响。 |
| 英文摘要: |
| Objective To explore the impact of preoperative human albumin (HA) administration on postoperative outcomes in elderly patients undergoing pancreaticoduodenectomy (PD).Methods A retrospective analysis was conducted on the clinical data of 351 elderly patients aged 65 or above who underwent pure PD at our hospital from January 2016 to December 2020.The propensity score matching method was used to analyze the clinical effects and postoperative outcomes between the HA group and the non-HA group.Results A total of 56 pairs (112 patients) were successfully matched using the propensity score matching method with an average age of 65-91 (70.6±4.8) years.There were no statistically significant differences in clinical baseline characteristics between the two groups after PSM (P>0.05).No differences were found between the HA group and the non-HA group in terms of operative time,intraoperative blood loss,postoperative hospital stay,total hospital stay and hospitalization costs (P>0.05).The incidence of overall postoperative complications,common complications such as pancreatic fistula,bile fistula,bleeding,and infection also showed no differences (P>0.05).There was a time effect on serum albumin in both groups,but the differences between the two groups were not significant,and there was no interaction effect.There were no statistical differences in ΔALB between the two groups (both P>0.05).Conclusions Preoperative administration of human albumin in elderly patients undergoing pure pancreaticoduodenectomy does not reduce intraoperative blood loss,operative time,or shorten hospital stay nor does it reduce the occurrence of postoperative complications,and it has no impact on the recovery of postoperative albumin levels. |
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